Evidence map›Paper›PMID 24746542›Full record

ArticleInternational journal of cardiology2014

Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography--the LURIC study.

Hubert Scharnagl, Marcus E Kleber, Bernd Genser, Sandra Kickmaier, Wilfried Renner, Gisela Weihrauch, Tanja Grammer, Christine Rossmann, Bernhard R Winkelmann, Bernhard O Boehm and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Hubert ScharnaglClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.
Marcus E KleberMedical Clinic V, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Bernd GenserMannheim Institute of Public Health, Medical Faculty Mannheim, Rupertus Carola University of Heidelberg, Mannheim, Germany.
Sandra KickmaierInstitute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Austria.
Wilfried RennerClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.
Gisela WeihrauchClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.
Tanja GrammerMedical Clinic V, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Christine RossmannInstitute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Austria.
Bernhard R WinkelmannClinPhenomics Study Center, Frankfurt, Germany.
Bernhard O BoehmUlm University Medical Centre, Department of Internal Medicine I, Ulm University, Ulm, Germany; LKC School of Medicine, Nanyang Technological University, Singapore and Imperial College London, UK.
Wolfgang SattlerInstitute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Austria.
Winfried MärzClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria; Medical Clinic V, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; Synlab Academy, Mannheim, Germany.
Ernst MalleInstitute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Austria. Electronic address: ernst.malle@medunigraz.at.
Medical University of Graz · ATUniversity Medical Centre Mannheim · DEHeidelberg University · DEImperial College London · GB

Funding

Austrian Science Fund FWF F 3007Austrian Science Fund FWF W 1226
6 · The paper itself

Abstract

backgroundThe phagocytic enzyme myeloperoxidase (MPO) acts as a front-line defender against microorganisms. However, increased MPO levels have been found to be associated with complex and calcified atherosclerotic lesions and incident cardiovascular disease. Therefore, this study aimed to investigate a predictive role of MPO, a biomarker of inflammation and oxidative stress, for total and cardiovascular mortality in patients referred to coronary angiography. METHODS AND

resultsMPO plasma concentrations along with eight MPO polymorphisms were determined in 3036 participants of the Ludwigshafen Risk and Cardiovascular Health study (median follow-up 7.75 years). MPO concentrations were positively associated with age, diabetes, smoking, markers of systemic inflammation (interleukin-6, fibrinogen, C-reactive protein, serum amyloid A) and vascular damage (vascular cellular adhesion molecule-1 and intercellular adhesion molecule-1) but negatively associated with HDL-cholesterol and apolipoprotein A-I. After adjustment for cardiovascular risk factors MPO concentrations in the highest versus the lowest quartile were associated with a 1.34-fold risk (95% CI: 1.09-1.67) for total mortality. In the adjusted model the hazard ratio for cardiovascular mortality in the highest MPO quartile was 1.42 (95% CI: 1.07-1.88). Five MPO polymorphisms were positively associated with MPO concentrations but not with mortality. Using Mendelian randomization, we did not obtain evidence for a causal association of MPO with either total or cardiovascular mortality.

conclusionsMPO concentrations but not genetic variants at the MPO locus are independently associated with risk for total and cardiovascular mortality in coronary artery disease patients.

Indexed as

Coronary AngiographyBiomarkersCardiovascular DiseasesFemaleHumansMaleMiddle AgedPeroxidasePolymorphism, GeneticPredictive Value of TestsRiskBiomarkersPeroxidaseCardiovascular mortalityHigh-density lipoproteinInflammationMyeloperoxidaseRisk factor

Identifiers

PMID24746542
PMCPMC4045190
OpenAlexW2010865078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.