Evidence map›Paper›PMID 24746053›Full record

ReviewProgress in brain research2014

Affective brain areas and sleep-disordered breathing.

Ronald M Harper, Rajesh Kumar, Paul M Macey, Mary A Woo, Jennifer A Ogren

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Sensing, feeling and regulating: investigating the association of focal brain damage with voluntary respiratory and motor control.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
  8. Article
  9. MRI findings in movement disorders and associated sleep disturbances.American journal of nuclear medicine and molecular imaging · 2023
    Review
  10. Article
  11. Breathing rate variability in obstructive sleep apnea during wakefulness.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. [Influences of severe obstructive sleep apnea on cognitive function].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ronald M HarperDepartment of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA, USA; Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA. Electronic address: rharper@ucla.edu.
Rajesh KumarDepartment of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA, USA; Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA.
Paul M MaceyBrain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA; UCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, USA.
Mary A WooUCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, USA.
Jennifer A OgrenUCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

Obstructive Sleep Apnea, Gender Biology, and Autonomic RegulationR01NR013693 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACEY, PAUL M · 2013 to 2017
$2.0M
Central Autonomic Nervous System Regulation in Heart FailureR01NR013625 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, WOO, MARY ANN · 2012 to 2015
$1.7M
Brain Axonal Injury in Obstructive Sleep ApneaR01HL113251 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH · 2012 to 2015
$1.4M
NHLBI NIH HHS R01 HL113251NHLBI NIH HHS R01 HL113251-01NINR NIH HHS R01 NR013625NINR NIH HHS R01 NR013625-01NINR NIH HHS R01 NR013693
6 · The paper itself

Abstract

The neural damage accompanying the hypoxia, reduced perfusion, and other consequences of sleep-disordered breathing, found in obstructive sleep apnea, heart failure, and congenital central hypoventilation syndrome (CCHS), appears in areas that serve multiple functions, including emotional drives to breathe, and involve systems that serve affective, cardiovascular, and breathing roles. The damage, assessed with structural magnetic resonance imaging (MRI) procedures, shows tissue loss or water content and diffusion changes indicative of injury, and impaired axonal integrity between structures; damage is preferentially unilateral. Functional MRI responses in affected areas also are time- or amplitude-distorted to ventilatory or autonomic challenges. Among the structures injured are the insular, cingulate, and ventral medial prefrontal cortices, as well as cerebellar deep nuclei and cortex, anterior hypothalamus, caudal raphé, ventrolateral medulla, portions of the basal ganglia and, in CCHS, the locus coeruleus. Caudal raphé and locus coeruleus injury have the potential to modify serotonergic and adrenergic modulation of upper airway and arousal characteristics, as well as affective drive to breathe. Since both axons and gray matter show injury, the consequences to function, especially to autonomic, cognitive, and mood regulation, are major. Several of the affected rostral sites mediate aspects of dyspnea, especially in CCHS, while others participate in initiation of inspiration after central breathing pauses, and the medullary injury can impair baroreflex and breathing control. The ancillary injury associated with sleep-disordered breathing to central structures can elicit multiple other distortions in cardiovascular, cognitive, and emotional functions in addition to effects on breathing regulation.

Indexed as

AnimalsBrainHumansSleep Apnea Syndromesbrainstemcongenital central hypoventilation syndromeheart failurehypothalamusmagnetic resonance imagingmedullaobstructive sleep apnea

Identifiers

PMID24746053
PMCPMC4060533
OpenAlexW1892117466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.