ReviewProgress in brain research2014
The integrative role of the sigh in psychology, physiology, pathology, and neurobiology.
Review in Progress in brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed.
- Brief structured respiration practices enhance mood and reduce physiological arousal.Cell reports. Medicine · 2023Trial
- A multi-level framework for the functions of emotions and their expressions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Dexterous single sniffs for ethological active olfaction.Science advances · 2026Article
- Neonatal inflammation induces lasting sex- and region-dependent microglia activation and sex-dependent impairments in chemoreflexes.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Sighs Shape Respiratory Variability and Pupil Dynamics and Adapt to Sustained Attention Demands.Psychophysiology · 2026Article
- Dissecting Cardiovascular Responses to a Fixed-Interval Volitional Sighing Protocol Using a Mixed Modeling Approach.Psychophysiology · 2026Article
- An objective method to detect sighs during cardio-pulmonary exercise testing.Scientific reports · 2025Article
- Stellate ganglion irradiation alleviates airway inflammation in asthmatic mice via activating SIRT1 signaling pathway.Scientific reports · 2025Article
- Sigh generation in preBötzinger complex.eLife · 2025Article
- Neuroanatomical and neurochemical organization of brainstem and forebrain circuits involved in breathing regulation.Journal of neurophysiology · 2025Review
- Interactions between Arousal State and COThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Review
- Cervical spinal cord hemisection impacts sigh and the respiratory reset in male rats.Physiological reports · 2024Article
- Surfing stress: A practical and paradigm changing approach to improving personal resilience.Future healthcare journal · 2024Article
- A comparative examination of morphine and fentanyl: unravelling the differential impacts on breathing and airway stability.The Journal of physiology · 2023Article
- Purinergic signaling mediates neuroglial interactions to modulate sighs.Nature communications · 2023Article
- A carotid body-brainstem neural circuit mediates sighing in hypoxia.Current biology : CB · 2023Article
- Sleep and Breathing Disturbances in Children With Leigh Syndrome: A Comparative Study.Pediatric neurology · 2022Article
- Temporal variations in the pattern of breathing: techniques, sources, and applications to translational sciences.The journal of physiological sciences : JPS · 2022Review
- The psychophysiology of the sigh: I: The sigh from the physiological perspective.Biological psychology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
"Sighs, tears, grief, distress" expresses Johann Sebastian Bach in a musical example for the relationship between sighs and deep emotions. This review explores the neurobiological basis of the sigh and its relationship with psychology, physiology, and pathology. Sighs monitor changes in brain states, induce arousal, and reset breathing variability. These behavioral roles homeostatically regulate breathing stability under physiological and pathological conditions. Sighs evoked in hypoxia evoke arousal and thereby become critical for survival. Hypoarousal and failure to sigh have been associated with sudden infant death syndrome. Increased breathing irregularity may provoke excessive sighing and hyperarousal, a behavioral sequence that may play a role in panic disorders. Essential for generating sighs and breathing is the pre-Bötzinger complex. Modulatory and synaptic interactions within this local network and between networks located in the brainstem, cerebellum, cortex, hypothalamus, amygdala, and the periaqueductal gray may govern the relationships between physiology, psychology, and pathology. Unraveling these circuits will lead to a better understanding of how we balance emotions and how emotions become pathological.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.