ArticleProgress in brain research2014
Rhythmic bursting in the pre-Bötzinger complex: mechanisms and models.
Article in Progress in brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Cellular properties and axonal projections of thyrotropin-releasing hormone-expressing neurons in the mouse lateral hypothalamic area.Journal of neurophysiology · 2026Article
- A Computational Model of the Respiratory CPG for the Artificial Control of Breathing.Bioengineering (Basel, Switzerland) · 2025Article
- Purinergic signaling mediates neuroglial interactions to modulate sighs.Nature communications · 2023Article
- Repeated applications of high potassium elicit long-term changes in a motor circuit from the crab,iScience · 2022Article
- Dynamic Rhythmogenic Network States Drive Differential Opioid Responses in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Correlation Analysis of Synchronization Type and Degree in Respiratory Neural Network.Computational intelligence and neuroscience · 2021Article
- Inhibitory control of active expiration by the Bötzinger complex in rats.The Journal of physiology · 2020Article
- Rapid adaptation to elevated extracellular potassium in the pyloric circuit of the crab,Journal of neurophysiology · 2020Article
- Article
- Increasing Local Excitability of Brainstem Respiratory Nuclei Reveals a Distributed Network Underlying Respiratory Motor Pattern Formation.Frontiers in physiology · 2019Article
- Kinetic properties of persistent NaThe Journal of general physiology · 2018Article
- Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus.The Journal of physiology · 2018Review
- Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.Physiology (Bethesda, Md.) · 2018Review
- Organization of the core respiratory network: Insights from optogenetic and modeling studies.PLoS computational biology · 2018Article
- Understanding the Generation of Network Bursts by Adaptive Oscillatory Neurons.Frontiers in neuroscience · 2018Article
- State-dependent rhythmogenesis and frequency control in a half-center locomotor CPG.Journal of neurophysiology · 2018Article
- Timescales and Mechanisms of Sigh-Like Bursting and Spiking in Models of Rhythmic Respiratory Neurons.Journal of mathematical neuroscience · 2017Article
- Synchronous Infra-Slow Bursting in the Mouse Accessory Olfactory Bulb Emerge from Interplay between Intrinsic Neuronal Dynamics and Network Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives.Current opinion in neurobiology · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The pre-Bötzinger complex (pre-BötC), a neural structure involved in respiratory rhythm generation, can generate rhythmic bursting activity in vitro that persists after blockade of synaptic inhibition. Experimental studies have identified two mechanisms potentially involved in this activity: one based on the persistent sodium current (INaP) and the other involving calcium (ICa) and/or calcium-activated nonspecific cation (ICAN) currents. In this modeling study, we investigated bursting generated in single neurons and excitatory neural populations with randomly distributed conductances of INaP and ICa. We analyzed the possible roles of these currents, the Na(+)/K(+) pump, synaptic mechanisms, and network interactions in rhythmic bursting generated under different conditions. We show that a population of synaptically coupled excitatory neurons with randomly distributed INaP- and/or ICAN-mediated burst generating mechanisms can operate in different oscillatory regimes with bursting dependent on either current or independent of both. The existence of multiple oscillatory regimes and their state dependence may explain rhythmic activities observed in the pre-BötC under different conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.