ArticleThe Journal of clinical investigation1989
Activation of monocytes and platelets by monoclonal antibodies or malaria-infected erythrocytes binding to the CD36 surface receptor in vitro.
Article in The Journal of clinical investigation, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 137 citations in OpenAlex.
- Characterizing mouse platelet heterogeneity across diverse disease models using spectral flow cytometry and high-dimensional analysis.Research and practice in thrombosis and haemostasis · 2026Article
- Pathophysiology of Cerebral Malaria: Implications of MSCs as A Regenerative Medicinal Tool.Bioengineering (Basel, Switzerland) · 2022Review
- Circulating soluble CD36 as a novel biomarker for progression and prognosis of HBV-related liver diseases.Frontiers in microbiology · 2022Article
- In vitro inhibition and reversal of Plasmodium falciparum cytoadherence to endothelium by monoclonal antibodies to ICAM-1 and CD36.Malaria journal · 2017Article
- Characterisation of Plasmodium falciparum populations selected on the human endothelial receptors P-selectin, E-selectin, CD9 and CD151.Scientific reports · 2017Article
- Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria.Journal of neuroinfectious diseases · 2014Article
- α-Thalassemia impairs the cytoadherence of Plasmodium falciparum-infected erythrocytes.PloS one · 2012Article
- A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria.PloS one · 2011Article
- Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome.PloS one · 2011Article
- Identification and characterization of class B scavenger receptor CD36 from the hard tick, Haemaphysalis longicornis.Parasitology research · 2011Article
- The role of platelets in the pathogenesis of cerebral malaria.Cellular and molecular life sciences : CMLS · 2010Review
- Platelets in defense against bacterial pathogens.Cellular and molecular life sciences : CMLS · 2010Review
- Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain.The Journal of clinical investigation · 2009Article
- Experimental conditions affect the outcome of Plasmodium falciparum platelet-mediated clumping assays.Malaria journal · 2008Article
- The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure.PLoS pathogens · 2008Article
- Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Platelet-induced clumping of Plasmodium falciparum-infected erythrocytes from Malawian patients with cerebral malaria-possible modulation in vivo by thrombocytopenia.The Journal of infectious diseases · 2008Article
- Optimal tumor necrosis factor induction by Plasmodium falciparum requires the highly localized release of parasite products.Infection and immunity · 2003Article
- CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum.Infection and immunity · 2003Article
- The terminal six amino-acids of the carboxy cytoplasmic tail of CD36 contain a functional domain implicated in the binding and capture of oxidized low-density lipoprotein.The Biochemical journal · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CD36 leukocyte differentiation antigen, recognized by MAbs OKM5 and OKM8 and found on human monocytes and endothelial cells, has been implicated as a sequestration receptor for erythrocytes infected with the human malaria parasite Plasmodium falciparum (IRBC). CD36 is also expressed on platelets and appears to be identical to platelet glycoprotein IV. We investigated receptor activation of monocytes and platelets by anti-CD36 MAbs and by IRBC. Incubation of human monocytes with anti-CD36 MAbs or IRBC resulted in stimulation of the respiratory burst as measured by reduction of nitroblue tetrazolium and generation of chemiluminescence. Incubation of human platelets with anti-CD36 MAbs resulted in platelet activation as measured by aggregation or ATP secretion. Activation of monocytes and platelets required appropriate intracellular transmembrane signaling and was inhibited by calcium antagonists or by specific inhibitors of protein kinase C or guanine nucleotide binding proteins. Soluble CD36 inhibited binding of IRBC to both monocytes and platelets, suggesting that these interactions are mediated by the CD36 receptor. Using a cytochemical electron microscopic technique, the presence of reactive oxygen intermediates was identified at the interface between human monocytes and IRBC. These data provide support for the hypothesis that reactive oxygen intermediates produced by monocytes when IRBC ligands interact with cell surface receptors may play a role in the pathophysiology of falciparum malaria.
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