Evidence map›Paper›PMID 24745633›Full record

ArticleAmerican journal of preventive medicine2014

Awareness of cancer susceptibility genetic testing: the 2000, 2005, and 2010 National Health Interview Surveys.

Phuong L Mai, Susan Thomas Vadaparampil, Nancy Breen, Timothy S McNeel, Louise Wideroff, Barry I Graubard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of preventive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Disparities in genetic services utilization in a random sample of young breast cancer survivors.Genetics in medicine : official journal of the American College of Medical Genetics · 2019
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  14. Barriers and interventions to improve the uptake of cancer risk management strategies in hereditary cancer syndromes: a narrative review.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2026
    Review
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Phuong L MaiDivision of Cancer Epidemiology and Genetics, NIH, Bethesda, Maryland. Electronic address: maip@mail.nih.gov.
Susan Thomas VadaparampilHealth Outcomes and Behavior Program, Moffitt Cancer Center and Department of Oncologic Sciences, College of Medicine, University of South Florida, Tampa, Florida.
Nancy BreenHealth Services and Economics Branch, Applied Research Program, National Cancer Institute, Office of the Director, Division of Basic Neuroscience and Behavioral Research, NIH, Bethesda, Maryland.
Timothy S McNeelInformation Management Services, Inc., Calverton, Maryland.
Louise WideroffNational Institute on Drug Abuse, NIH, Bethesda, Maryland.
Barry I GraubardDivision of Cancer Epidemiology and Genetics, NIH, Bethesda, Maryland.

Funding

Clinical Genetic Studies of Familial and Hereditary Cancer SyndromesZIACP010144 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$111.8M
Intramural NIH HHS ZIA CP010144
6 · The paper itself

Abstract

backgroundGenetic testing for several cancer susceptibility syndromes is clinically available; however, existing data suggest limited population awareness of such tests. PURPOSE: To examine awareness regarding cancer genetic testing in the U.S. population aged ≥25 years in the 2000, 2005, and 2010 National Health Interview Surveys.

methodsThe weighted percentages of respondents aware of cancer genetic tests, and percent changes from 2000-2005 and 2005-2010, overall and by demographic, family history, and healthcare factors were calculated. Interactions were used to evaluate the patterns of change in awareness between 2005 and 2010 among subgroups within each factor. To evaluate associations with awareness in 2005 and 2010, percentages were adjusted for covariates using multiple logistic regression. The analysis was performed in 2012.

resultsAwareness decreased from 44.4% to 41.5% (p<0.001) between 2000 and 2005, and increased to 47.0% (p<0.001) in 2010. Awareness increased between 2005 and 2010 in most subgroups, particularly among individuals in the South (pinteraction=0.03) or with a usual place of care (pinteraction=0.01). In 2005 and 2010, awareness was positively associated with personal or family cancer history and high perceived cancer risk, and inversely associated with racial/ethnic minorities, age 25-39 or ≥60 years, male gender, lower education and income levels, public or no health insurance, and no provider contact in 12 months.

conclusionsDespite improvement from 2005 to 2010, ≤50% of the U.S. adult population was aware of cancer genetic testing in 2010. Notably, disparities persist for racial/ethnic minorities and individuals with limited health care access or income.

Indexed as

AwarenessAdultAgedAge FactorsFemaleGenetic TestingHealth SurveysHumansMaleMiddle AgedNeoplasmsRacial GroupsRisk AssessmentSex FactorsSocioeconomic FactorsUnited States

Identifiers

PMID24745633
PMCPMC4042677

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.