Evidence map›Paper›PMID 24745471›Full record

ArticlePsychiatry research2014

The BDNF Val66Met polymorphism does not moderate the effect of self-reported physical activity on depressive symptoms in midlife.

Swathi Gujral, Stephen B Manuck, Robert E Ferrell, Janine D Flory, Kirk I Erickson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Review
  3. Regulatory Molecules of Synaptic Plasticity in Anxiety Disorder.International journal of general medicine · 2023
    Review
  4. Article
  5. Interaction Effect between Physical Activity and theInternational journal of environmental research and public health · 2022
    Article
  6. Article
  7. Review
  8. Establishing a Scientific Consensus on the Cognitive Benefits of Physical Activity.International journal of environmental research and public health · 2019
    Article
  9. Article
  10. Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Swathi GujralDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
Stephen B ManuckDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
Robert E FerrellDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Janine D FloryDepartment of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
Kirk I EricksonDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: kiericks@pitt.edu.
Center for the Neural Basis of Cognition · USIcahn School of Medicine at Mount Sinai · USUniversity of Pittsburgh · US

Funding

Substrates of Threat and Reward Sensitivity and CVD RiskP01HL040962 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 1988 to 2022
$31.1M
Influence of Physical Activity and Weight Loss on Brain PlasticityR01DK095172 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2012 to 2016
$2.1M
NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSIONR01HL065137 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANUCK, STEPHEN B · 2000 to 2003
$1.5M
NHLBI NIH HHS P01 HL040962NHLBI NIH HHS P01HL040962NHLBI NIH HHS R01 HL065137NHLBI NIH HHS R01HL065137NIDDK NIH HHS R01 DK095172NIDDK NIH HHS R01DK095172
6 · The paper itself

Abstract

The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism may be associated with clinical and subsyndromal depression, but physical activity improves mood and increases BDNF expression. The aim of the study was to examine whether the BDNF polymorphism moderates an effect of physical activity on depressive symptoms. BDNF genotype, physical activity measured by the Paffenbarger Questionnaire, and depressive symptoms using the Center for Epidemiology Depression Scale (CES-D) were collected on 1072 participants (mean age=44). Multiple linear regression was used to examine the association between BDNF genotype, physical activity, and depressive symptoms. After adjusting for family income, age, and education, depressive symptoms were higher in Met carriers compared to Val homozygotes (p=0.03), but this was only significant in men. Physical activity was associated with fewer depressive symptoms, but only in women (p=0.01). BDNF genotype did not moderate the effect of physical activity on depressive symptoms (p=0.94). In midlife, the BDNF Val66Met polymorphism neither attenuates nor magnifies the effect of physical activity on depressive symptoms.

Indexed as

AffectPolymorphism, Single NucleotideAdultBrain-Derived Neurotrophic FactorDepressionExerciseFemaleGenotypeHumansMaleMiddle AgedMotor ActivityPsychiatric Status Rating ScalesSelf ReportSurveys and QuestionnairesBrain-Derived Neurotrophic FactorBDNF polymorphismDepressionExercise

Identifiers

PMID24745471
PMCPMC4059542
OpenAlexW2142106468

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.