Trial reportBMC veterinary research2014
Randomized clinical trial to evaluate the pathogenicity of Bibersteinia trehalosi in respiratory disease among calves.
Trial report in BMC veterinary research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Respiratory Bacteria and Antimicrobial Resistance Genes Detected by Long-Read Metagenomic Sequencing Following Feedlot Arrival, Subsequent Treatment Risk and Phenotypic Resistance in Feedlot Calves.Antibiotics (Basel, Switzerland) · 2025Article
- Differential identification of Mannheimia haemolytica genotypes 1 and 2 using colorimetric loop-mediated isothermal amplification.BMC research notes · 2023Article
- Influence of Single Dose Enrofloxacin Injection on Development of Fluoroquinolone Resistance inAntibiotics (Basel, Switzerland) · 2022Article
- Effect of Danofloxacin Treatment on the Development of Fluoroquinolone Resistance inAntibiotics (Basel, Switzerland) · 2022Article
- Bovine Respiratory Disease: Conventional to Culture-Independent Approaches to Studying Antimicrobial Resistance in North America.Antibiotics (Basel, Switzerland) · 2022Review
- Comparisons of plasma and fecal pharmacokinetics of danofloxacin and enrofloxacin in healthy and Mannheimia haemolytica infected calves.Scientific reports · 2022Article
- Enrofloxacin Alters Fecal Microbiota and Resistome Irrespective of Its Dose in Calves.Microorganisms · 2021Article
- Danofloxacin Treatment Alters the Diversity and Resistome Profile of Gut Microbiota in Calves.Microorganisms · 2021Article
- Use of Thoracic Ultrasonography to Improve Disease Detection in Experimental BRD Infection.Frontiers in veterinary science · 2021Article
- Single-Use (Disposable) Flexible Bronchoscopes: The Future of Bronchoscopy?Advances in therapy · 2020Review
- Bovine Respiratory Disease Diagnosis: What Progress Has Been Made in Infectious Diagnosis?The Veterinary clinics of North America. Food animal practice · 2020Review
- Whole-Genome Sequence of Multidrug-Resistant Bibersteinia trehalosi Strain OADDL-BT1.Microbiology resource announcements · 2019Article
- Relationship between nasopharyngeal and bronchoalveolar microbial communities in clinically healthy feedlot cattle.BMC microbiology · 2017Article
- Lessons for livestock genomics from genome and transcriptome sequencing in cattle and other mammals.Genetics, selection, evolution : GSE · 2016Article
- Serum concentrations of haptoglobin and haptoglobin-matrix metalloproteinase 9 (Hp-MMP 9) complexes of bovine calves in a bacterial respiratory challenge model.BMC veterinary research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBibersteinia trehalosi causes respiratory disease in ruminants particularly in wild and domestic sheep. Recently, there has been an increased number of B. trehalosi isolates obtained from diagnostic samples from bovine respiratory disease cases. This study evaluated the role of B. trehalosi in bovine respiratory disease using an intra-tracheal inoculation model in calves. Thirty six cross bred 2-3 month old dairy calves were inoculated intra-tracheally with either leukotoxin negative B. trehalosi, leukotoxin positive B. trehalosi isolate, Mannheimia haemolytica, a combination of leukotoxin negative B. trehalosi and M. haemolytica or negative control. Calves were euthanized and necropsy performed on day 10 of study.
resultsB. trehalosi inoculated calves did not have increased lung involvement compared to control calves. Additionally, B. trehalosi was only cultured once from the lungs of inoculated calves at necropsy.
conclusionsBased on these findings B. trehalosi may not be a primary pathogen of respiratory disease in cattle. Culture of B. trehalosi from diagnostic submissions should not be immediately identified as a primary cause of respiratory disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.