Evidence map›Paper›PMID 24745008›Full record

ReviewBioMed research international2014

Comparative evaluation of recombinant protein production in different biofactories: the green perspective.

Matilde Merlin, Elisa Gecchele, Stefano Capaldi, Mario Pezzotti, Linda Avesani

Abstract readReview
In one paragraph

Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

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  16. 3 Biotech · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matilde MerlinDepartment of Biotechnology, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-1978-9235
Elisa GeccheleDepartment of Biotechnology, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-1133-4140
Stefano CapaldiDepartment of Biotechnology, University of Verona, 37134 Verona, Italy.
Mario PezzottiDepartment of Biotechnology, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-7430-6147
Linda AvesaniDepartment of Biotechnology, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-4007-7013

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the production of recombinant pharmaceutical proteins in heterologous systems has increased significantly. Most applications involve complex proteins and glycoproteins that are difficult to produce, thus promoting the development and improvement of a wide range of production platforms. No individual system is optimal for the production of all recombinant proteins, so the diversity of platforms based on plants offers a significant advantage. Here, we discuss the production of four recombinant pharmaceutical proteins using different platforms, highlighting from these examples the unique advantages of plant-based systems over traditional fermenter-based expression platforms.

Indexed as

Biological ProductsCloning, MolecularGreen Chemistry TechnologyPlants, Genetically ModifiedProtein EngineeringRecombinant ProteinsBiological ProductsRecombinant Proteins

Identifiers

PMID24745008
PMCPMC3972949

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.