ArticlePhysiological reports2014
Poststimulation inhibition of the micturition reflex induced by tibial nerve stimulation in rats.
Article in Physiological reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A First-In-Human Feasibility Study of a New Implantable Tibial Nerve Stimulator for Overactive Bladder Syndrome.Neuromodulation : journal of the International Neuromodulation Society · 2025Trial
- Transcutaneous electrical stimulation of somatic afferent nerves in the foot relieved symptoms related to postoperative bladder spasms.BMC urology · 2017Trial
- Tibial nerve stimulation for overactive bladder: a literature review of stimulation parameters.Translational andrology and urology · 2026Review
- The mechanism of action of neuromodulation in the treatment of overactive bladder.Nature reviews. Urology · 2025Review
- Prolonged inhibition of bladder function is evoked by low-amplitude electrical stimulation of the saphenous nerve in urethane-anesthetized rats.Physiological reports · 2022Article
- Early Transcutaneous Tibial Nerve Stimulation Acutely Improves Lower Urinary Tract Function in Spinal Cord Injured Rats.Neurotrauma reports · 2022Article
- Indwelling urinary catheter assembled with lidocaine-loaded polymeric strand for local sustained alleviation of bladder discomfort.Bioengineering & translational medicine · 2021Article
- The long-lasting post-stimulation inhibitory effects of bladder activity induced by posterior tibial nerve stimulation in unanesthetized rats.Scientific reports · 2020Article
- Recruitment of unmyelinated C-fibers mediates the bladder-inhibitory effects of tibial nerve stimulation in a continuous-fill anesthetized rat model.American journal of physiology. Renal physiology · 2019Article
- Characterizing the transcutaneous electrical recruitment of lower leg afferents in healthy adults: implications for non-invasive treatment of overactive bladder.BMC urology · 2018Article
- Inhibitory effects of tibial nerve stimulation on bladder neurophysiology in rats.SpringerPlus · 2016Article
- Impact of Bioelectronic Medicine on the Neural Regulation of Pelvic Visceral Function.Bioelectronic medicine · 2015Article
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Authors and funding
4 authors.
Funding
Abstract
The purpose of this study was to determine the effect of tibial nerve stimulation (TNS) on the micturition reflex. Experiments were conducted in 24 rats under urethane anesthesia. A catheter was inserted into the bladder via the bladder dome for saline infusion. A cuff electrode was placed around right tibial nerve for stimulation. TNS (5 Hz, 0.2 msec pulse width) at 2-4 times the threshold (T) intensity for inducing a toe movement was applied either during slow (0.08 mL/min) infusion of the bladder or for 30 min with an empty bladder. TNS had no effect on the micturition reflex when it was applied during slow bladder infusion. However, the 30-min TNS applied with an empty bladder induced poststimulation inhibition and significantly (P < 0.05) increased the bladder capacity to about 140% of prestimulation level in a 50-min period following the termination of stimulation. The bladder compliance was also significantly (P < 0.05) increased after the 30-min TNS. These results suggest that different mechanisms might exist in acute- and post-TNS inhibition of micturition reflex. The animal model developed in this study will be very useful for further investigations of the neurotransmitter mechanisms underlying tibial neuromodulation of bladder function.
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