ArticlePhysiological reports2014
Combined reflectance spectroscopy and stochastic modeling approach for noninvasive hemoglobin determination via palpebral conjunctiva.
Article in Physiological reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Development of a Deep Learning Model to Estimate Anemia from Palpebral Conjunctiva Taken with a Portable Slit-Lamp Microscope.Bioengineering (Basel, Switzerland) · 2026Article
- Article
- Radiomic identification of anemia features in monochromatic conjunctiva photographs in school-age children.Biophotonics discovery · 2025Article
- Diffuse reflectance spectroscopy and RGB-imaging: a comparative study of non-invasive haemoglobin assessment.Scientific reports · 2024Article
- Ocular images-based artificial intelligence on systemic diseases.Biomedical engineering online · 2023Review
- Emerging point-of-care technologies for anemia detection.Lab on a chip · 2021Review
- Noninvasive Hemoglobin Level Prediction in a Mobile Phone Environment: State of the Art Review and Recommendations.JMIR mHealth and uHealth · 2021Article
- Article
- A Kalman Filtering and Nonlinear Penalty Regression Approach for Noninvasive Anemia Detection with Palpebral Conjunctiva Images.Journal of healthcare engineering · 2017Article
- Parkinson's disease-associated melanin steal.Neuropsychiatric disease and treatment · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A combination of stochastic photon propagation model in a multilayered human eyelid tissue and reflectance spectroscopy was used to study palpebral conjunctiva spectral reflectance for hemoglobin (Hgb) determination. The developed model is the first biologically relevant model of eyelid tissue, which was shown to provide very good approximation to the measured spectra. Tissue optical parameters were defined using previous histological and microscopy studies of a human eyelid. After calibration of the model parameters the responses of reflectance spectra to Hgb level and blood oxygenation variations were calculated. The stimulated reflectance spectra in adults with normal and low Hgb levels agreed well with experimental data for Hgb concentrations from 8.1 to 16.7 g/dL. The extracted Hgb levels were compared with in vitro Hgb measurements. The root mean square error of cross-validation was 1.64 g/dL. The method was shown to provide 86% sensitivity estimates for clinically diagnosed anemia cases. A combination of the model with spectroscopy measurements provides a new tool for noninvasive study of human conjunctiva to aid in diagnosing blood disorders such as anemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.