Evidence map›Paper›PMID 24744784›Full record

ReviewInternational journal of endocrinology2014

Activation of toll-like receptors and inflammasome complexes in the diabetic cardiomyopathy-associated inflammation.

J Fuentes-Antrás, A M Ioan, J Tuñón, J Egido, O Lorenzo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

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  17. The Macrophage Iron Signature in Health and Disease.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

J Fuentes-AntrásCardiovascular Research Laboratory, IIS-Fundación Jiménez Díaz, Autónoma University, Avenida Reyes Católicos 2, 28040 Madrid, Spain.
A M IoanCardiovascular Research Laboratory, IIS-Fundación Jiménez Díaz, Autónoma University, Avenida Reyes Católicos 2, 28040 Madrid, Spain.
J TuñónCardiovascular Research Laboratory, IIS-Fundación Jiménez Díaz, Autónoma University, Avenida Reyes Católicos 2, 28040 Madrid, Spain.
J EgidoCardiovascular Research Laboratory, IIS-Fundación Jiménez Díaz, Autónoma University, Avenida Reyes Católicos 2, 28040 Madrid, Spain ; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM) Network, Avenida Reyes Católicos 2, 28040 Madrid, Spain.
O LorenzoCardiovascular Research Laboratory, IIS-Fundación Jiménez Díaz, Autónoma University, Avenida Reyes Católicos 2, 28040 Madrid, Spain ; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM) Network, Avenida Reyes Católicos 2, 28040 Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic cardiomyopathy is defined as a ventricular dysfunction initiated by alterations in cardiac energy substrates in the absence of coronary artery disease and hypertension. Hyperglycemia, hyperlipidemia, and insulin resistance are major inducers of the chronic low-grade inflammatory state that characterizes the diabetic heart. Cardiac Toll-like receptors and inflammasome complexes may be key inducers for inflammation probably through NF-κB activation and ROS overproduction. However, metabolic dysregulated factors such as peroxisome proliferator-activated receptors and sirtuins may serve as therapeutic targets to control this response by mitigating both Toll-like receptors and inflammasome signaling.

Identifiers

PMID24744784
PMCPMC3972909

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.