ReviewFrontiers in physiology2014
Motifs in the permeation pathway of connexin channels mediate voltage and Ca (2+) sensing.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Connexin Gap Junction Channels and Hemichannels: Insights from High-Resolution Structures.Biology · 2024Review
- Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest.Life science alliance · 2023Article
- Connexin and Pannexin Large-Pore Channels in Microcirculation and Neurovascular Coupling Function.International journal of molecular sciences · 2022Review
- Connexin 43 Gene Ablation Does Not Alter Human Pluripotent Stem Cell Germ Lineage Specification.Biomolecules · 2021Article
- Pannexins and Connexins: Their Relevance for Oocyte Developmental Competence.International journal of molecular sciences · 2021Review
- Mechanisms Underlying Connexin Hemichannel Activation in Disease.International journal of molecular sciences · 2021Review
- Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating.International journal of molecular sciences · 2020Article
- Connexin 26 and Connexin 43 in Canine Mammary Carcinoma.Veterinary sciences · 2019Article
- Electrical coupling and its channels.The Journal of general physiology · 2018Review
- The weak voltage dependence of pannexin 1 channels can be tuned by N-terminal modifications.The Journal of general physiology · 2018Article
- Article
- Direct Cell⁻Cell Interactions in the Endometrium and in Endometrial Pathophysiology.International journal of molecular sciences · 2018Review
- Interactions of Pannexin1 channels with purinergic and NMDA receptor channels.Biochimica et biophysica acta. Biomembranes · 2018Review
- Modulation of Connexin-36 Gap Junction Channels by Intracellular pH and Magnesium Ions.Frontiers in physiology · 2018Article
- Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.Pharmacological reviews · 2017Review
- Genomic instability induced in distant progeny of bystander cells depends on the connexins expressed in the irradiated cells.International journal of radiation biology · 2017Article
- The electrical synapse: Molecular complexities at the gap and beyond.Developmental neurobiology · 2017Review
- Cell coupling mediated by connexin 26 selectively contributes to reduced adhesivity and increased migration.Journal of cell science · 2016Article
- Calcium homeostasis modulator (CALHM) ion channels.Pflugers Archiv : European journal of physiology · 2016Review
- The double life of connexin channels: single is a treat.The Journal of investigative dermatology · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Connexin channels mediate electrical coupling, intercellular molecular signaling, and extracellular release of signaling molecules. Connexin proteins assemble intracellularly as hexamers to form plasma membrane hemichannels. The docking of two hemichannels in apposed cells forms a gap junction channel that allows direct electrical and selective cytoplasmic communication between adjacent cells. Hemichannels and junctional channels are gated by voltage, but extracellular Ca (2+) also gates unpaired plasma membrane hemichannels. Unlike other ion channels, connexin channels do not contain discrete voltage- or Ca (2+)-sensing modules linked to a separate pore-forming module. All studies to date indicate that voltage and Ca (2+) sensing are predominantly mediated by motifs that lie within or are exposed to the pore lumen. The sensors appear to be integral components of the gates, imposing an obligatory structural linkage between sensing and gating not commonly present in other ion channels, in which the sensors are semi-independent domains distinct from the pore. Because of this, the structural and electrostatic features that define connexin channel gating also define pore permeability properties, and vice versa; analysis/mutagenesis of gating and of permeability properties are linked. This offers unique challenges and opportunities for elucidating mechanisms of ligand and voltage-driven gating.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.