ArticleFrontiers in neuroanatomy2014
Distribution of GABAergic cells in the inferior colliculus that project to the thalamus.
Article in Frontiers in neuroanatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
- Binaural Processing Deficits in Autism Spectrum Disorder.Audiology research · 2026Review
- Age-related differences in asymmetric synapses across the central inferior colliculus in the Fischer Brown Norway rat.Aging brain · 2026Article
- Age-related ultrastructural differences in the dorsal cortex of the inferior colliculus in the fischer brown Norway rat.Neurobiology of aging · 2026Article
- Ultrastructural characterization of neuropeptide Y synapses in the central inferior colliculus of the Fischer Brown Norway rat.Neuropeptides · 2025Article
- Anatomical and neurochemical profiles of GABAergic projection neurons in the mouse inferior colliculus.Brain structure & function · 2025Article
- Age-related differences in GABAergic synapses across the central inferior colliculus in the Fischer Brown Norway rat.Neurobiology of aging · 2025Article
- Contextual auditory processing in the inferior colliculus is affected in a sex- and age-dependent manner in the valproic acid-induced rat model of autism.PLoS biology · 2025Article
- Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats.Frontiers in aging neuroscience · 2025Article
- The histological development of the fetal human inferior colliculus during the second trimester.Frontiers in neuroanatomy · 2024Article
- Age-related upregulation of perineuronal nets on inferior collicular cells that project to the cochlear nucleus.Frontiers in aging neuroscience · 2023Article
- Age-related Changes of GAD1 mRNA Expression in the Central Inferior Colliculus.Translational medicine of aging · 2023Article
- Age-related ultrastructural changes in the lateral cortex of the inferior colliculus.Neurobiology of aging · 2022Article
- Inhibitory NPY Neurons Provide a Large and Heterotopic Commissural Projection in the Inferior Colliculus.Frontiers in neural circuits · 2022Article
- Inferior collicular cells that project to the auditory thalamus are increasingly surrounded by perineuronal nets with age.Neurobiology of aging · 2021Article
- Neuropeptide Y Expression Defines a Novel Class of GABAergic Projection Neuron in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Density of Perineuronal Nets Increases With Age in the Inferior Colliculus in the Fischer Brown Norway Rat.Frontiers in aging neuroscience · 2020Article
- Subtypes of GABAergic cells in the inferior colliculus.Hearing research · 2019Review
- A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice.eLife · 2019Article
- Bilateral projections to the thalamus from individual neurons in the inferior colliculus.The Journal of comparative neurology · 2019Article
- Inhibitory Projections in the Mouse Auditory Tectothalamic System.Brain sciences · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
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Abstract
A GABAergic component has been identified in the projection from the inferior colliculus (IC) to the medial geniculate body (MG) in cats and rats. We sought to determine if this GABAergic pathway exists in guinea pig, a species widely used in auditory research. The guinea pig IC contains GABAergic cells, but their relative abundance in the IC and their relative contributions to tectothalamic projections are unknown. We identified GABAergic cells with immunochemistry for glutamic acid decarboxylase (GAD) and determined that ~21% of IC neurons are GABAergic. We then combined retrograde tracing with GAD immunohistochemistry to identify the GABAergic tectothalamic projection. Large injections of Fast Blue, red fluorescent beads or FluoroGold were deposited to include all subdivisions of the MG. The results demonstrate a GABAergic pathway from each IC subdivision to the ipsilateral MG. GABAergic cells constitute ~22% of this ipsilateral pathway. In addition, each subdivision of the IC had a GABAergic projection to the contralateral MG. Measured by number of tectothalamic cells, the contralateral projection is about 10% of the size of the ipsilateral projection. GABAergic cells constitute about 20% of the contralateral projection. In summary, the results demonstrate a tectothalamic projection in guinea pigs that originates in part from GABAergic cells that project ipsilaterally or contralaterally to the MG. The results show similarities to both rats and cats, and carry implications for the role of GABAergic tectothalamic projections vis-à-vis the presence (in cats) or near absence (in rats and guinea pigs) of GABAergic interneurons in the MG.
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