ArticleTurkish journal of haematology : official journal of Turkish Society of Haematology2012
The Frequency of Mutations in Exon 11 of the c-kit Gene in Patients With Leukemia.
Article in Turkish journal of haematology : official journal of Turkish Society of Haematology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Pathologic complete response to neoadjuvant imatinib of a gastric stromal tumor with concomitant mutations inClinical case reports · 2023Article
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5 authors.
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Abstract
objectiveTo determine the frequency of mutations in exon 11 of the c-kit gene in patients with leukemia. MATERIAL AND
methodsThe study included 50 leukemia patients (31 with acute myeloid leukemia, 5 with acutelymphoblastic leukemia, 9 with chronic myeloid leukemia, and 5 with chronic lymphocytic leukemia) that underwentPCR-SSCP, followed by direct DNA sequencing.
resultsIn all, 28 of the leukemia patients were male and 22 were female, with a mean age of 31.88 years (range: 2-65years). In total, 20 mutations in 19 patients were identified, including Lys550Asn, Tyr568Ser, Ile571Thr, Thr574Pro,Gln575His, Tyr578Pro, Asp579His, His580Gln, Arg586Thr, Asn587Asp, and Arg588Met, as well as novel point mutationsat codons Ile563Lys, Val569Leu, Tyr570Ser, and Pro577Ser. Ile571Leu substitution was observed in 2 patients andTrp582Ser substitution was observed in 3 patients.
conclusionThe results suggest that mutations in exon 11 of the c-kit gene might be useful as molecular geneticmarkers for leukemia.
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