Evidence map›Paper›PMID 24744600›Full record

ReviewWorld journal of gastroenterology2014

Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer.

Yun-Feng Wang, Fei-Ling Feng, Xu-Hong Zhao, Zhen-Xiong Ye, He-Ping Zeng, Zhen Li, Xiao-Qing Jiang, Zhi-Hai Peng

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 194 citations in OpenAlex.

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  19. Research progress on prognostic factors of gallbladder carcinoma.Journal of cancer research and clinical oncology · 2024
    Review
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yun-Feng WangYun-Feng Wang, Zhi-Hai Peng, Department of Hepatobiliary Surgery, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China.
Fei-Ling FengYun-Feng Wang, Zhi-Hai Peng, Department of Hepatobiliary Surgery, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China.
Xu-Hong ZhaoYun-Feng Wang, Zhi-Hai Peng, Department of Hepatobiliary Surgery, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China.
Zhen-Xiong YeYun-Feng Wang, Zhi-Hai Peng, Department of Hepatobiliary Surgery, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China.
He-Ping ZengYun-Feng Wang, Zhi-Hai Peng, Department of Hepatobiliary Surgery, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China.
Zhen LiYun-Feng Wang, Zhi-Hai Peng, Department of Hepatobiliary Surgery, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China.
Xiao-Qing JiangYun-Feng Wang, Zhi-Hai Peng, Department of Hepatobiliary Surgery, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China.
Zhi-Hai PengYun-Feng Wang, Zhi-Hai Peng, Department of Hepatobiliary Surgery, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China.
Shandong Provincial QianFoShan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo clarify the value of combined use of markers for the diagnosis of gallbladder cancer and prediction of its prognosis.

methodsSerum cancer antigens (CA)199, CA242, carcinoembryonic antigen (CEA), and CA125 levels were measured in 78 patients with gallbladder cancer (GBC), 78 patients with benign gallbladder diseases, and 78 healthy controls using electrochemiluminescence. CA199, CA242, CEA, and CA125 levels and positive rates were analyzed and evaluated pre- and post-operatively. Receiver operator characteristic curves were used to determine diagnostic sensitivity and specificity of GBC. Survival time analysis, including survival curves, and multivariate survival analysis of a Cox proportional hazards model was performed to evaluate independent prognostic factors.

resultsSerum CA242, CA125, and CA199 levels in the GBC group were significantly higher when compared with those in the benign gallbladder disease and healthy control groups (P < 0.01). With a single tumor marker for GBC diagnosis, the sensitivity of CA199 was the highest (71.7%), with the highest specificity being in CA242 (98.7%). Diagnostic accuracy was highest with a combination of CA199, CA242, and CA125 (69.2%). CA242 could be regarded as a tumor marker of GBC infiltration in the early stage. The sensitivity of CA199 and CA242 increased with progression of GBC and advanced lymph node metastasis (P < 0.05). The 78 GBC patients were followed up for 6-12 mo (mean: 8 mo), during which time serum CA199, CA125, and CA242 levels in the recurrence group were significantly higher than in patients without recurrence (P < 0.01). The post-operative serum CA199, CA125, and CA242 levels in the non-recurrence group were significantly lower than those in the GBC group (P < 0.01). Multivariate survival analysis using a Cox proportional hazards model showed that cancer of the gallbladder neck and CA199 expression level were independent prognostic factors.

conclusionCA242 is a marker of GBC infiltration in the early stage. CA199 and cancer of the gallbladder neck are therapeutic and prognostic markers.

Indexed as

Gene Expression Regulation, NeoplasticAdultAgedAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorCA-125 AntigenFemaleGallbladder DiseasesGallbladder NeoplasmsHumansLymphatic MetastasisMaleMembrane ProteinsMiddle AgedMultivariate AnalysisPrognosisAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorCA-125 AntigenCA 242 antigencarbohydrate antigen 199, humanMembrane ProteinsMUC16 protein, humanCombined detectionDiagnosisGallbladder cancerPrognosisTumor marker

Identifiers

PMID24744600
PMCPMC3983467
OpenAlexW2045246672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.