Evidence map›Paper›PMID 24744571›Full record

ReviewWorld journal of gastroenterology2014

Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation.

Chun Seng Lee, Elizabeth J Ryan, Glen A Doherty

2 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 111 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 2 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03833570 phase2completednot on this mapstarted 2018, after this paper: background citation

The Effectiveness of Melatonin in Prevention of Radiation-induced Oral Mucositis

TypeinterventionalSponsorHams Hamed AbdelrahmanRan2018 to 2018Enrolled40ConditionsOral Mucositis (Ulcerative) Due to RadiationArmsRapid Release Capsules Melatonin, 10 mg, Miconaz oral gel, BBC oral spray, Oracure gel, Alkamisr sachets
NCT04308161 phase2unknown statusnot on this mapstarted 2019, after this paper: background citation

The Effectiveness of Topical Oral Vitamin D Gel in Prevention of Radiation-induced Oral Mucositis

TypeinterventionalSponsorHams Hamed AbdelrahmanRan2019 to 2020Enrolled45ConditionsOral Mucositis Due to RadiationArmsvitamin D oral gel, Miconazole Topical Gel, BBC oral spray, Oracure gel, Alkamisr sachets
3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 2 syntheses or guidelines pooled it, 222 citations in OpenAlex.

  1. Exploring the links among inflammation and gut microbiome with psychoneurological symptoms and gastrointestinal toxicities in gynecologic cancers: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chun Seng LeeChun Seng Lee, Elizabeth J Ryan, Glen A Doherty, Centre for Colorectal Disease, St. Vincent's University Hospital, Dublin 4, Ireland.
Elizabeth J RyanChun Seng Lee, Elizabeth J Ryan, Glen A Doherty, Centre for Colorectal Disease, St. Vincent's University Hospital, Dublin 4, Ireland.
Glen A DohertyChun Seng Lee, Elizabeth J Ryan, Glen A Doherty, Centre for Colorectal Disease, St. Vincent's University Hospital, Dublin 4, Ireland.
St. Vincent's University Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy-induced diarrhea (CID) is a common and often severe side effect experienced by colorectal cancer (CRC) patients during their treatment. As chemotherapy regimens evolve to include more efficacious agents, CID is increasingly becoming a major cause of dose limiting toxicity and merits further investigation. Inflammation is a key factor behind gastrointestinal (GI) toxicity of chemotherapy. Different chemotherapeutic agents activate a diverse range of pro-inflammatory pathways culminating in distinct histopathological changes in the small intestine and colonic mucosa. Here we review the current understanding of the mechanisms behind GI toxicity and the mucositis associated with systemic treatment of CRC. Insights into the inflammatory response activated during this process gained from various models of GI toxicity are discussed. The inflammatory processes contributing to the GI toxicity of chemotherapeutic agents are increasingly being recognised as having an important role in the development of anti-tumor immunity, thus conferring added benefit against tumor recurrence and improving patient survival. We review the basic mechanisms involved in the promotion of immunogenic cell death and its relevance in the treatment of colorectal cancer. Finally, the impact of CID on patient outcomes and therapeutic strategies to prevent or minimise the effect of GI toxicity and mucositis are discussed.

Indexed as

AnimalsAntibodies, MonoclonalAntineoplastic AgentsCamptothecinCell DeathColorectal NeoplasmsDiarrheaDisease Models, AnimalFluorouracilGastrointestinal DiseasesGastrointestinal TractHumansInflammationIntestinal MucosaIrinotecanMucositisAntibodies, MonoclonalAntineoplastic AgentsCamptothecinFluorouracilIrinotecanOrganoplatinum CompoundsOxaliplatinChemotherapyDiarrheaImmunogenic cell deathPro-inflammatory cytokinesSide-effects

Identifiers

PMID24744571
PMCPMC3983434
OpenAlexW2006330201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.