ArticleIndian journal of urology : IJU : journal of the Urological Society of India2014
Pharmacology of the lower urinary tract.
Article in Indian journal of urology : IJU : journal of the Urological Society of India, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 17 citations in OpenAlex.
- Possible role of transient receptor potential melastatin 4 channels in adrenergic contractions in mouse prostate smooth muscles.The Journal of veterinary medical science · 2023Article
- Purinergic smooth muscle contractions in the human prostate: estimation of relevance and characterization of different agonists.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Re: Efficacy of tadalafil treatment in erectile dysfunction in patients receiving dutasteride treatment: A prospective nonrandomized comparative study.Turkish journal of urology · 2019Article
- An immunohistochemical identification key for cell types in adult mouse prostatic and urethral tissue sections.PloS one · 2017Article
- New therapeutic strategies for the treatment of male lower urinary tract symptoms.Research and reports in urology · 2016Review
- Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864.British journal of pharmacology · 2015Article
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3 authors at 1 institution in 1 country.
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Abstract
Pharmacology of the lower urinary tract provides the basis for medical treatment of lower urinary tract symptoms (LUTS). Therapy of LUTS addresses obstructive symptoms (frequently explained by increased prostate smooth muscle tone and prostate enlargement) in patients with benign prostate hyperplasia (BPH) and storage symptoms in patients with overactive bladder (OAB). Targets for medical treatment include G protein-coupled receptors (α1-adrenoceptors, muscarinic acetylcholine receptors, β3-adrenoceptors) or intracellular enzymes (5α-reductase; phosphodiesterase-5, PDE5). Established therapies of obstructive symptoms aim to induce prostate smooth muscle relaxation by α1-blockers or PDE5 inhibitors, or to reduce prostate growth and volume with 5α-reductase inhibitors. Available options for treatment of OAB comprise anitmuscarinics, β3-adrenoceptor agonists, and botulinum toxin A, which improve storage symptoms by inhibition of bladder smooth muscle contraction. With the recent approval of β3-antagonists, PDE inhibitors, and silodosin for therapy of LUTS, progress from basic research of lower urinary tract pharmacology was translated into new clinical applications. Further targets are in preclinical stages of examination, including modulators of the endocannabinoid system and transient receptor potential (TRP) channels.
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