Evidence map›Paper›PMID 24744467›Full record

ArticleBiology of sport2013

The +1245g/t polymorphisms in the collagen type I alpha 1 (col1a1) gene in polish skiers with anterior cruciate ligament injury.

M Stępien-Słodkowska, K Ficek, J Eider, A Leońska-Duniec, A Maciejewska-Karłowska, M Sawczuk, A Zarębska, Z Jastrzębski, A Grenda, K Kotarska and 1 more

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In one paragraph

Article in Biology of sport, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

M Stępien-SłodkowskaUniversity of Szczecin, Department of Physical Culture and Health Promotion, Szczecin, Poland.
K FicekUniversity of Szczecin, Department of Physical Culture and Health Promotion, Szczecin, Poland ; Galen Medical Center, Bieruń, Poland.
J EiderUniversity of Szczecin, Department of Physical Culture and Health Promotion, Szczecin, Poland.
A Leońska-DuniecUniversity of Szczecin, Department of Physical Culture and Health Promotion, Szczecin, Poland ; Academy of Physical Education and Sport, Department of Sport Education, Gdańsk, Poland.
A Maciejewska-KarłowskaUniversity of Szczecin, Department of Physical Culture and Health Promotion, Szczecin, Poland ; University of Szczecin, Department of Genetics, Poland.
M SawczukUniversity of Szczecin, Department of Physical Culture and Health Promotion, Szczecin, Poland ; University of Szczecin, Department of Genetics, Poland.
A ZarębskaAcademy of Physical Education and Sport, Department of Sport Education, Gdańsk, Poland.
Z JastrzębskiAcademy of Physical Education and Sport, Department of Sport Education, Gdańsk, Poland.
A GrendaWest Pomeranian Technological University, Department of Physical Education and Sport, Szczecin, Poland.
K KotarskaUniversity of Szczecin, Department of Physical Culture and Health Promotion, Szczecin, Poland.
P CięszczykAcademy of Physical Education and Sport, Department of Sport Education, Gdańsk, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to examine the association of +1245G/T polymorphisms in the COL1A1 gene with ACL ruptures in Polish male recreational skiers in a case-control study.

methodsA total of 138 male recreational skiers with surgically diagnosed primary ACL ruptures, all of whom qualified for ligament reconstruction, were recruited for this study. The control group comprised 183 apparently healthy male skiers with a comparable level of exposure to ACL injury, none of whom had any self-reported history of ligament or tendon injury. DNA samples extracted from the oral epithelial cells were genotyped for the +1245G/T polymorphisms using real-time PCR method.

resultsGenotype distributions among cases and controls conformed to Hardy-Weinberg equilibrium (p = 0.2469 and p = 0.33, respectively). There was a significant difference in the genotype distribution between skiers and controls (p = 0.045, Fisher's exact test). There was no statistical difference in allele distribution: OR 1.43 (0.91-2.25), p = 0.101 (two-sided Fisher's exact test).

conclusionsThe risk of ACL ruptures was around 1.43 times lower in carriers of a minor allele G as compared to carriers of the allele T.

Indexed as

anterior cruciate ligament (ACL) ruptureCOL1A1 genecollagenpolymorphismskiers

Identifiers

PMID24744467
PMCPMC3944561

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.