ArticleSleep2014
Developmental patterns of sleep slow wave activity and synaptic density in adolescent mice.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- High Resolution Topography of Age-Related Changes in Non-Rapid Eye Movement Sleep Electroencephalography.PloS one · 2016Trial
- A biopsychosocial approach to sleep health during puberty: Individual and contextual aspects and the role of gender differences. A narrative review.Cogent mental health · 2025Review
- A Thalamocortical Perspective on Sleep Spindle Alterations in Neurodevelopmental Disorders.Current sleep medicine reports · 2024Review
- Adolescent sleep shapes social novelty preference in mice.Nature neuroscience · 2022Article
- Chronic intermittent ethanol during adolescence and adulthood alters dendritic spines in the primary motor and visual cortex in rats.Alcohol (Fayetteville, N.Y.) · 2021Article
- Longitudinal Analysis of Sleep Spindle Maturation from Childhood through Late Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Ontogenesis of Mammalian Sleep: Form and Function.Current sleep medicine reports · 2020Article
- Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex.Neural development · 2020Article
- Experience and sleep-dependent synaptic plasticity: from structure to activity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Disruption of Rapid Eye Movement Sleep Homeostasis in Adolescent Rats after Neonatal Anesthesia.Anesthesiology · 2019Article
- Article
- Sleep and Wake Affect Glycogen Content and Turnover at Perisynaptic Astrocytic Processes.Frontiers in cellular neuroscience · 2018Article
- Cortical Up states induce the selective weakening of subthreshold synaptic inputs.Nature communications · 2017Article
- Sleep/wake movement velocities, trajectories and micro-arousals during maturation in rats.BMC neuroscience · 2017Article
- Article
- Review
- Synaptic refinement during development and its effect on slow-wave activity: a computational study.Journal of neurophysiology · 2016Article
- Loss of Sleep Affects the Ultrastructure of Pyramidal Neurons in the Adolescent Mouse Frontal Cortex.Sleep · 2016Article
- Cortical development, electroencephalogram rhythms, and the sleep/wake cycle.Biological psychiatry · 2015Review
- Lempel-Ziv complexity of cortical activity during sleep and waking in rats.Journal of neurophysiology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectiveIn humans sleep slow wave activity (SWA) declines during adolescence. It has been suggested that this decline reflects the elimination of cortical synapses, but this hypothesis has never been tested directly.
designWe focused on mouse frontal cortex and collected data from early adolescence (∼postnatal day 20, P20) to adulthood (P60) of (1) SWA; (2) expression of synapsin I, a presynaptic marker; and (3) number of dendritic spines in layers I-II.
settingBasic sleep research laboratory. PATIENTS OR
participantsYFP-line H mice (n = 70; P15-87, all males) and GFP-line S mice (n = 14; P17-60, 8 females) were used for EEG recording. Forty-five YFP mice (P19-119, 12 females) and 42 GFP-S mice (P20-60, 14 females) were used for in vivo 2-photon imaging and ex vivo confocal microscopy, respectively. Other YGP mice (n = 57, P10-77) were used for western blot analysis of synapsin I.
interventionsN/A. MEASUREMENTS AND
resultsAs in humans, SWA in mice declined from early adolescence to adulthood. Synapsin I levels increased from P10 to P24, with little change afterwards. Mean spine density in apical dendrites of layer V pyramidal neurons (YFP-H) showed no change from P20 to P60. Spine number in layers I-II apical dendrites, belonging to layer III and V pyramidal neurons (GFP-S), increased slightly from P20 to P30 and decreased from P30 to P60; smaller spines decreased in number from P20 to P60, while bigger spines increased.
conclusionsIn mice, it is unlikely that the developmental decrease in SWA can be accounted for by a net pruning of cortical synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.