ArticleScience (New York, N.Y.)2014
Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex.
Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 319 papers.
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Who cites it
319 citing papers in PubMed.
- Article
- Comparative Systematic Analysis of Gray Matter Biophysical Models on a Public Dataset.Magnetic resonance in medicine · 2026Article
- Does perturbed adaptive myelination contribute to cognitive dysfunction in Alzheimer's disease?PLoS biology · 2026Article
- Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader-Willi syndrome.The Journal of physiology · 2026Article
- Zebrafish oligodendrocyte lineage cells use the postsynaptic protein Gephyrin to myelinate GABAergic axons and limit myelin sheath growth.Nature communications · 2026Article
- Cortical and white matter myelination proceed in concert during early infancy.Nature communications · 2026Article
- Molecular cues from distinct neuron classes drive differential myelination in the neocortex.Developmental cell · 2026Article
- Transcriptional Heterogeneity of Oligodendrocytes: Molecular Basis of Diversity Across Development, Brain Regions, and Neurological Diseases.Neurology international · 2026Review
- Mechanisms underlying spontaneous and evoked calcium responses in oligodendrocyte precursor cells: A modeling investigation.PLoS computational biology · 2026Article
- Article
- On hyperbolicity for nerve pulse propagation in axons.Journal of computational neuroscience · 2026Article
- Multiple adhesion molecules act together in oligodendrocyte-mediated axonal selection and myelin formation.PLoS biology · 2026Article
- Mapping corpus callosum architecture: developmental, genetic, and cognitive correlates in youth.bioRxiv : the preprint server for biology · 2026Article
- Article
- Cognitive Stimulation and Activity-Dependent Myelination: Oligodendroglial Mechanisms Linking Neural Activity and Brain Plasticity.International journal of molecular sciences · 2026Review
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury.Cell · 2026Article
- Two axes of white matter development.Nature communications · 2026Article
- Differential Myeloarchitecture of Subfields of the Mammalian Auditory Cortex: A Comparative Approach.Brain, behavior and evolution · 2026Review
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
259 more citing papers are in PubMed but not listed here.
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9 authors.
Funding
Abstract
Myelin is a defining feature of the vertebrate nervous system. Variability in the thickness of the myelin envelope is a structural feature affecting the conduction of neuronal signals. Conversely, the distribution of myelinated tracts along the length of axons has been assumed to be uniform. Here, we traced high-throughput electron microscopy reconstructions of single axons of pyramidal neurons in the mouse neocortex and built high-resolution maps of myelination. We find that individual neurons have distinct longitudinal distribution of myelin. Neurons in the superficial layers displayed the most diversified profiles, including a new pattern where myelinated segments are interspersed with long, unmyelinated tracts. Our data indicate that the profile of longitudinal distribution of myelin is an integral feature of neuronal identity and may have evolved as a strategy to modulate long-distance communication in the neocortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.