ArticleHuman genetics2014
Conditions for the validity of SNP-based heritability estimation.
Article in Human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The genetics of early-onset bipolar disorder: A systematic review.Journal of affective disorders · 2015Pooled it
- The estimation of additive genetic variance of body size in a wild passerine is sensitive to the method used to estimate relatedness among the individuals.Ecology and evolution · 2024Article
- Biobank-scale methods and projections for sparse polygenic prediction from machine learning.Scientific reports · 2023Article
- Multivariate estimation of factor structures of complex traits using SNP-based genomic relationships.BMC bioinformatics · 2022Article
- 8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer.Nature communications · 2020Article
- Missing heritability of complex diseases: case solved?Human genetics · 2020Review
- Estimation of metabolic syndrome heritability in three large populations including full pedigree and genomic information.Human genetics · 2019Article
- Biologically Defined or Biologically Informed Traits Are More Heritable Than Clinically Defined Ones: The Case of Oral and Dental Phenotypes.Advances in experimental medicine and biology · 2019Article
- The accuracy of LD Score regression as an estimator of confounding and genetic correlations in genome-wide association studies.Genetic epidemiology · 2018Article
- Exploring the genetic correlations of antisocial behaviour and life history traits.BJPsych open · 2018Article
- Accurate Genomic Prediction of Human Height.Genetics · 2018Article
- Statistical properties of simple random-effects models for genetic heritability.Electronic journal of statistics · 2018Article
- Partitioning Phenotypic Variance Due to Parent-of-Origin Effects Using Genomic Relatedness Matrices.Behavior genetics · 2018Article
- On the reconciliation of missing heritability for genome-wide association studies.European journal of human genetics : EJHG · 2016Article
- Application of linear mixed models to study genetic stability of height and body mass index across countries and time.International journal of epidemiology · 2016Article
- Uncovering the Genetic Architectures of Quantitative Traits.Computational and structural biotechnology journal · 2016Review
- Misspecification in Mixed-Model-Based Association Analysis.Genetics · 2016Article
- The Fourth Law of Behavior Genetics.Current directions in psychological science · 2015Article
- Applying compressed sensing to genome-wide association studies.GigaScience · 2014Article
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2 authors.
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Abstract
The heritability of a trait (h(2)) is the proportion of its population variance caused by genetic differences, and estimates of this parameter are important for interpreting the results of genome-wide association studies (GWAS). In recent years, researchers have adopted a novel method for estimating a lower bound on heritability directly from GWAS data that uses realized genetic similarities between nominally unrelated individuals. The quantity estimated by this method is purported to be the contribution to heritability that could in principle be recovered from association studies employing the given panel of SNPs (h(2)(SNP)). Thus far, the validity of this approach has mostly been tested empirically. Here, we provide a mathematical explication and show that the method should remain a robust means of obtaining h(2)(SNP)) under circumstances wider than those under which it has so far been derived.
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