Trial reportEuropean radiology2014
Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with ¹⁵O-H₂O PET.
Trial report in European radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03324308 (The Safety, Feasibility and Accuracy of Dynamic Computed Tomography Myocardial Perfusion Imaging for Detection of Coronary Artery Disease), which is not on this map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Safety, Feasibility and Accuracy of Dynamic Computed Tomography Myocardial Perfusion Imaging for Detection of Coronary Artery Disease
Who cites it
41 citing papers in PubMed.
- Super-Resolution Deep Learning Reconstruction Improves Image Quality of Dynamic Myocardial Computed Tomography Perfusion Imaging.Tomography (Ann Arbor, Mich.) · 2026Article
- Protocol optimization and myocardial blood flow quantification in dynamic myocardial perfusion CT-where do we stand?European radiology · 2025Article
- Effect of sampling rate during dynamic myocardial CT perfusion on coronary flow reserve and ischemia analysis.The international journal of cardiovascular imaging · 2025Article
- Integrating myocardial CT perfusion with coronary CT angiography improves risk stratification in patients with dialysis-dependent end-stage renal disease.Japanese journal of radiology · 2025Article
- How to perform and evaluate a myocardial perfusion imaging by computed tomography.European heart journal. Imaging methods and practice · 2025Review
- Preliminary experience with dynamic CT myocardial perfusion imaging: a single-centre perspective.Polish journal of radiology · 2025Article
- Accuracy of dynamic stress CT myocardial perfusion in patients with suspected non-ST elevation myocardial infarction.The international journal of cardiovascular imaging · 2025Article
- Diagnostic value of computed tomography myocardial perfusion imaging to detect coexisting microvascular dysfunction in patients with obstructive epicardial coronary artery disease.Quantitative imaging in medicine and surgery · 2023Article
- Dynamic CT Myocardial Perfusion: The Role of Functional Evaluation in the Diagnosis of Coronary Artery Disease.Journal of clinical medicine · 2023Review
- Dynamic myocardial CT perfusion imaging-state of the art.European radiology · 2023Review
- A Novel CT Perfusion-Based Fractional Flow Reserve Algorithm for Detecting Coronary Artery Disease.Journal of clinical medicine · 2023Article
- Feasibility of four-dimensional similarity filter for radiation dose reduction in dynamic myocardial computed tomography perfusion imaging.Frontiers in radiology · 2023Article
- Static CT myocardial perfusion imaging: image quality, artifacts including distribution and diagnostic performance compared toEuropean journal of hybrid imaging · 2022Article
- [Beyond Coronary CT Angiography: CT Fractional Flow Reserve and Perfusion].Taehan Yongsang Uihakhoe chi · 2022Review
- Dual-Energy Heart CT: Beyond Better Angiography-Review.Journal of clinical medicine · 2021Review
- Clinical Validation of the Accuracy of Absolute Myocardial Blood Flow Quantification with Dual-Source CT UsingRadiology. Cardiothoracic imaging · 2021Article
- Computed tomography calls out nuclear imaging in its field: It doesn't matter how you are searching but what you are looking for.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- The value of coronary computed tomography angiography in assessing the cardiac circulation of an outpatient-based population.Medicine · 2020Article
- Clinical application of four-dimensional noise reduction filtering with a similarity algorithm in dynamic myocardial computed tomography perfusion imaging.The international journal of cardiovascular imaging · 2020Observational
- Computed tomographic evaluation of myocardial ischemia.Japanese journal of radiology · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against (15)O-H₂O positron-emission tomography (PET) and assesses the CFRs of coronary artery disease (CAD) patients.
methodsThirty-two subjects underwent both dynamic CT perfusion (CTP) and PET perfusion imaging at rest and during pharmacological stress. In 12 normal subjects (pilot group), the calculation method for MBF and CFR was established. In the other 13 normal subjects (validation group), MBF and CFR obtained by dynamic CTP and PET were compared. Finally, the CFRs obtained by dynamic CTP and PET were compared between the validation group and CAD patients (n = 7).
resultsCorrelation between MBF of MDCT and PET was strong (r = 0.95, P < 0.0001). CFR showed good correlation between dynamic CTP and PET (r = 0.67, P = 0.0126). CFRCT in the CAD group (2.3 ± 0.8) was significantly lower than that in the validation group (5.2 ± 1.8) (P = 0.0011).
conclusionsWe established a method for measuring MBF and CFR with the relatively low-dose dynamic MDCT. Lower CFR was well demonstrated in CAD patients by dynamic CTP. KEY POINTS: • MBF and CFR can be calculated using dynamic CTP with 320-row MDCT. • MBF and CFR showed good correlation between dynamic CTP and PET. • Lower CFR was well demonstrated in CAD patients by dynamic CTP.
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Registered trials
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