ArticleClinical rheumatology2014
Cytospin preparations are superior to common smears in the detection of monosodium urate crystals in low-cellular synovial fluids.
Article in Clinical rheumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Laboratory testing of extravascular body fluids: National recommendations on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine. Part II - Synovial fluid.Biochemia medica · 2020Guideline
- A Multicenter Collaborative Survey of Peritoneal Lavage Cytology in Gastric Cancer Surgery: Interinstitutional Methodological Differences and Positive Rate.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Article
- Serum/Synovial Fluid Urate Ratio as an Indicator for Distinguishing Gouty Arthritis From Other Arthritides.Archives of rheumatology · 2019Article
- Diagnostic advances in synovial fluid analysis and radiographic identification for crystalline arthritis.Current opinion in rheumatology · 2019Review
- The added value of synovial fluid centrifugation for monosodium urate and calcium pyrophosphate crystal detection.Clinical rheumatology · 2017Article
- Gadolinium-enhanced MRI features of acute gouty arthritis on top of chronic gouty involvement in different joints.Clinical rheumatology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In cases of gout with a low synovial fluid (SF) leukocyte count and atypical clinical presentation, such as in intercritical periods, the load of monosodium urate (MSU) crystals is frequently low, and thus, methods to improve the crystal detection may be beneficial. We compared the MSU crystal detection rates between cytospin slides and common smear preparations in low-cellular (<2,000/μl) SF samples of patients with gout. We determined the number of MSU crystals/15 high power fields (HPF) at × 1,000 magnification by polarised microscopy in cytospin preparations and smears in SF samples of 17 patients with MSU-crystal-proven gout and compared the two methods statistically. All of the cytospin slides (100 %) contained MSU crystals and showed a median number of 124 crystals/15 HPF (range 2-3,915), whereas 5 of the 17 smears (29 %) were MSU-crystal-negative, with a median count of 2 crystals/15 HPF (range 0-430/HPF). The difference was statistically highly significant (p < 0.0001). In conclusion, we have shown that the cytospin technique is superior to smears in the detection of MSU crystals in SF with a low SF leukocyte count. In light of our observations, we recommend the use of cytocentrifuges for routine crystal analysis in such cases.
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