Trial reportThe European respiratory journal2014
Quantitative imaging of airway liquid absorption in cystic fibrosis.
Trial report in The European respiratory journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01223183 (Absorptive Clearance After Inhaled Osmotics in Cystic Fibrosis), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Absorptive Clearance After Inhaled Osmotics in Cystic Fibrosis
Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Overnight delivery of hypertonic saline by nasal cannula aerosol for cystic fibrosis.Pediatric pulmonology · 2017Trial
- In vitro inhibition of the CFTR ion channel in the Macaca mulatta cervix thickens cervical mucus†.Biology of reproduction · 2025Article
- Imaging drug delivery to the lungs: Methods and applications in oncology.Advanced drug delivery reviews · 2023Review
- Nasal epithelial cell culture fluorescence recovery after photobleaching predicts cystic fibrosis therapeutic response.ERJ open research · 2022Article
- Article
- Mucociliary Clearance Scans Show Infants Undergoing Congenital Cardiac Surgery Have Poor Airway Clearance Function.Frontiers in cardiovascular medicine · 2021Article
- Excess mucus viscosity and airway dehydration impact COPD airway clearance.The European respiratory journal · 2020Article
- A physiologically-motivated model of cystic fibrosis liquid and solute transport dynamics across primary human nasal epithelia.Journal of pharmacokinetics and pharmacodynamics · 2019Article
- Multiprobe Nuclear Imaging of the Cystic Fibrosis Lung as a Biomarker of Therapeutic Effect.Journal of aerosol medicine and pulmonary drug delivery · 2019Article
- TheThe European respiratory journal · 2018Article
- Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT.Nanoscale · 2017Article
- Pseudomonas infection and mucociliary and absorptive clearance in the cystic fibrosis lung.The European respiratory journal · 2016Article
- Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype.Annals of the American Thoracic Society · 2016Review
- Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2015Article
- Article
- Osmolytes and ion transport modulators: new strategies for airway surface rehydration.Current opinion in pharmacology · 2010Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
New measures are needed to rapidly assess emerging treatments for cystic fibrosis (CF) lung disease. Using an imaging approach, we evaluated the absorptive clearance of the radiolabeled small molecule probe diethylene triamine penta-acetic acid (DTPA) as an in vivo indicator of changes in airway liquid absorption. DTPA absorption and mucociliary clearance rates were measured in 21 patients with CF (12 adults and nine children) and nine adult controls using nuclear imaging. The effect of hypertonic saline on DTPA absorption was also studied. In addition, in vitro studies were conducted to identify the determinants of transepithelial DTPA absorption. CF patients had significantly increased rates of DTPA absorption compared with control subjects but had similar mucociliary clearance rates. Treatment with hypertonic saline resulted in a decrease in DTPA absorption and an increase in mucociliary clearance in 11 out of 11 adult CF patients compared with treatment with isotonic saline. In vitro studies revealed that ∼ 50% of DTPA absorption can be attributed to transepithelial fluid transport. Apically applied mucus impedes liquid and DTPA absorption. However, mucus effects become negligible in the presence of an osmotic stimulus. Functional imaging of DTPA absorption provides a quantifiable marker of immediate response to treatments that promote airway surface liquid hydration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.