ReviewCurrent gastroenterology reports2014
New therapies for non-cardiac chest pain.
Review in Current gastroenterology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Treatment efficacy for non-cardiovascular chest pain: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Bacillus coagulans TCI803 confers gastroesophageal protection against Helicobacter pylori -evoked gastric oxidative stress and acid-induced lower esophageal sphincter inflammation.Journal of the Chinese Medical Association : JCMA · 2025Article
- Diagnosis and Management of Functional Chest Pain in the Rome IV Era.Journal of neurogastroenterology and motility · 2019Review
- Observational
- Association of atrial fibrillation and gastroesophageal reflux disease: Natural and therapeutic linkage of the two common diseases.Journal of arrhythmia · 2019Review
- Non-Cardiac Chest Pain: A Review of Environmental Exposure-Associated Comorbidities and Biomarkers.EMJ. Gastroenterology · 2018Article
- The Proton Pump Inhibitor Non-Responder: A Clinical Conundrum.Clinical and translational gastroenterology · 2015Article
- Peroral endoscopic myotomy: an evolving treatment for achalasia.Nature reviews. Gastroenterology & hepatology · 2015Review
- Use of Clostridium botulinum toxin in gastrointestinal motility disorders in children.World journal of gastrointestinal endoscopy · 2015Article
- Treatment of esophageal motility disorders based on the chicago classification.Current treatment options in gastroenterology · 2014Article
- Esophageal hypomotility and spastic motor disorders: current diagnosis and treatment.Current gastroenterology reports · 2014Review
- Comparison the effect of Asvard capsule and omeprazole in treatment and recurrence of non-cardiac chest pain related to gastroesophageal reflux disease in adults: A controlled double blind clinical trial.Avicenna journal of phytomedicineArticle
- [Approach to the Patient with Non-cardiogenic Chest Pain of Esophageal Origin].Acta gastroenterologica LatinoamericanaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After excluding a cardiac cause, potent anti-reflux therapy should be administered to patients with non-cardiac chest pain since gastroesophageal reflux disease (GERD) is the most common underlying mechanism of this disorder. If GERD is an unlikely cause of patient's symptoms, an esophageal motor disorder should be excluded. Spastic motility disorders can be treated with a smooth muscle relaxant (such as calcium channel blocker, nitrate, or phosphodiesterase 5 inhibitors). Alternatively, spastic motility disorders may respond to anti-spasmodics, pain modulators, botulinum toxin injection into the distal esophagus, and/or surgery. Patients with functional chest pain have recently seen an expanded treatment armamentarium including medications such as trazadone, tricyclic anti-depressants, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, pregabalin, and/or ramelteon.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.