SynthesisInternational urology and nephrology2014
Reducing the risk of infection for transrectal prostate biopsy with povidone-iodine: a systematic review and meta-analysis.
Synthesis in International urology and nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Infection risk reduction with povidone-iodine rectal disinfection prior to transrectal prostate biopsy: an updated systematic review and meta-analysis.World journal of urology · 2024Pooled it
- Rectal Culture-Based Versus Empirical Antibiotic Prophylaxis to Prevent Infectious Complications in Men Undergoing Transrectal Prostate Biopsy: A Randomized, Nonblinded Multicenter Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Trial
- A prospective randomized trial of povidone-iodine suppository before transrectal ultrasonography-guided prostate biopsy.Medicine · 2019Trial
- Povidone-iodine for transrectal prostate biopsy.The Cochrane database of systematic reviews · 2025Article
- Correction: Infection risk reduction with povidone-iodine rectal disinfection prior to transrectal prostate biopsy: an updated systematic review and meta-analysis.World journal of urology · 2024Article
- Clinical Value of a Routine Urine Culture Prior to Transrectal Prostate Biopsy.European urology open science · 2023Article
- Infection complications after transrectal ultrasound-guided prostate biopsy: A radiology department's experience and strategy for improvement.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022Article
- Topical antiseptic at time of transrectal ultrasound prostate biopsy is associated with fewer severe clinical infections and improves antibiotic stewardship.Prostate international · 2021Article
- Transrectal povidone-iodine efficiency in reducing infections occurring after transrectal ultrasound guided biopsy of the prostate.Medicine · 2021Article
- Transrectal ultrasound biopsy of the prostate: does it still have a role in prostate cancer diagnosis?Translational andrology and urology · 2020Review
- A New Nomogram Allowing Physicians to Predict Patients at High Risk of Fever Occurring After Prostate Biopsy.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Current routines for antibiotic prophylaxis prior to transrectal prostate biopsy: a national survey to all urology clinics in Sweden.F1000Research · 2020Article
- [Importance of magnetic resonance imaging/ultrasound-guided fusion biopsy for the detection and monitoring of prostate cancer].Der Urologe. Ausg. A · 2019Article
- Topical rectal antiseptic at time of prostate biopsy: how a resident patient safety project has evolved into institutional practice.International urology and nephrology · 2018Article
- [Prophylaxis of infectious complications following prostate biopsy].Der Urologe. Ausg. A · 2017Review
- TransperinealTranslational andrology and urology · 2017Review
- Reducing Infectious Complications Following Transrectal Ultrasound-guided Prostate Biopsy: A Systematic Review.Reviews in urology · 2016Article
- The emerging threat of multidrug-resistant Gram-negative bacteria in urology.Nature reviews. Urology · 2015Review
- Efficacy of two-time prophylactic intravenous administration of tazobactam/piperacillin for transrectal ultrasound-guided needle biopsy of the prostate.Prostate international · 2015Article
- Complications of transrectal ultrasound-guided prostate biopsy: impact of prebiopsy enema.Korean journal of urology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the efficacy of povidone-iodine (PI) in reducing the risk of infectious complications following transrectal prostate biopsy (TRPB).
methodsEligible randomized controlled trials (RCTs) were identified from electronic databases (Cochrane CENTRAL, MEDLINE, and EMBASE). The database search, quality assessment, and data extraction were performed independently by two reviewers. The main outcome for the efficacy of PI was the incidence of infectious complications after TRPB.
resultsSeven trials, including 2,049 patients, met the inclusion criteria. Data from the seven included RCTs favored the use of PI before TRPB to prevent infectious complications. PI for "PI versus blank control" significantly reduced fever, bacteriuria, and bacteremia compared with that for control [relative risk (RR) 0.31; 95 % confidence interval (CI) 0.21-0.45, P < 0.00001]. With PI versus antibiotics (ATB), patients treated with ATB alone had a significantly greater risk of bacteremia (RR 0.38; 95 % CI 0.16-0.90, P = 0.03). In "PI plus ATB versus ATB" trials, the risk of fever (RR 0.11; 95 % CI 0.02-0.85, P = 0.03) and bacteremia (RR 0.25; 95 % CI 0.08-0.75, P = 0.01) was diminished in the "PI plus ATB" group.
conclusionsRectal disinfection with PI provides a safe and effective method to reduce the risk of infectious complications following TRPB, regardless of mono-prophylaxis and combined prophylaxis with PI and ATB. Large, multicenter, and prospective RCTs of good quality trials are needed to confirm the efficacy of PI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.