ArticlePLoS pathogens2014
Kind discrimination and competitive exclusion mediated by contact-dependent growth inhibition systems shape biofilm community structure.
Article in PLoS pathogens, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- Evolution-proof inhibitors of public good cooperation: a screening strategy inspired by social evolution theory.FEMS microbiology reviews · 2022Article
- Recipient Cell Factors Influence Interbacterial Competition Mediated by Two Distinct Burkholderia dolosa Contact-Dependent Growth Inhibition Systems.Journal of bacteriology · 2022Article
- Kin discrimination drives territorial exclusion during Bacillus subtilis swarming and restrains exploitation of surfactin.The ISME journal · 2022Article
- The Type VII Secretion System ofAnnual review of microbiology · 2021Article
- Burkholderia multivorans requires species-specific GltJK for entry of a contact-dependent growth inhibition system protein.Molecular microbiology · 2021Article
- rpoS-mutation variants are selected in Pseudomonas aeruginosa biofilms under imipenem pressure.Cell & bioscience · 2021Article
- Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms.PLoS genetics · 2021Article
- The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins.Nature communications · 2021Article
- A Heterogeneously Expressed Gene Family Modulates the Biofilm Architecture and Hypoxic Growth ofmBio · 2021Article
- Contact-Dependent Growth Inhibition in Bacteria: Do Not Get Too Close!International journal of molecular sciences · 2020Review
- Bacterial Community Interactions During Chronic Respiratory Disease.Frontiers in cellular and infection microbiology · 2020Review
- Double Tubular Contractile Structure of the Type VI Secretion System Displays Striking Flexibility and Elasticity.Journal of bacteriology · 2019Article
- Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins.Structure (London, England : 1993) · 2019Article
- Spatial Organization of Expanding Bacterial Colonies Is Affected by Contact-Dependent Growth Inhibition.Current biology : CB · 2019Article
- Conditional quorum-sensing induction of a cyanide-insensitive terminal oxidase stabilizes cooperating populations of Pseudomonas aeruginosa.Nature communications · 2019Article
- Biofilm-associated toxin and extracellular protease cooperatively suppress competitors in Bacillus subtilis biofilms.PLoS genetics · 2019Article
- The Cytoplasm-Entry Domain of Antibacterial CdiA Is a Dynamic α-Helical Bundle with Disulfide-Dependent Structural Features.Journal of molecular biology · 2019Article
- Burkholderia cepacia Complex Contact-Dependent Growth Inhibition Systems Mediate Interbacterial Competition.Journal of bacteriology · 2019Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Contact-Dependent Growth Inhibition (CDI) is a phenomenon in which bacteria use the toxic C-terminus of a large exoprotein (called BcpA in Burkholderia species) to inhibit the growth of neighboring bacteria upon cell-cell contact. CDI systems are present in a wide range of Gram-negative proteobacteria and a hallmark feature is polymorphism amongst the exoprotein C-termini (BcpA-CT in Burkholderia) and amongst the small immunity proteins (BcpI) that protect against CDI in an allele-specific manner. In addition to CDI, the BcpAIOB proteins of Burkholderia thailandensis mediate biofilm formation, and they do so independent of BcpA-mediated interbacterial competition, suggesting a cooperative role for CDI system proteins in this process. CDI has previously only been demonstrated between CDI+ and CDI- bacteria, leaving the roles of CDI system-mediated interbacterial competition and of CDI system diversity in nature unknown. We constructed B. thailandensis strains that differed only in the BcpA-CT and BcpI proteins they produced. When co-cultured on agar, these strains each participated in CDI and the outcome of the competition depended on both CDI system efficiency and relative bacterial numbers initially. Strains also participated in CDI during biofilm development, resulting in pillar structures that were composed of only a single BcpA-CT/BcpI type. Moreover, a strain producing BcpA-CT/BcpI proteins of one type was prevented from joining a pre-established biofilm community composed of bacteria producing BcpA-CT/BcpI proteins of a different type, unless it also produced the BcpI protein of the established strain. Bacteria can therefore use CDI systems for kind recognition and competitive exclusion of 'non-self' bacteria from a pre-established biofilm. Our data indicate that CDI systems function in both cooperative and competitive behaviors to build microbial communities that are composed of only bacteria that are related via their CDI system alleles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.