ReviewEndocrine connections2014
The appraisal of chronic stress and the development of the metabolic syndrome: a systematic review of prospective cohort studies.
Review in Endocrine connections, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 5 syntheses or guidelines pooled it, 208 citations in OpenAlex.
- A Systematic Review of Physical Health Consequences and Acculturation Stress Among Latinx Individuals in the United States.Biological research for nursing · 2021Pooled it
- Influence of Regular Physical Activity and Fitness on Stress Reactivity as Measured with the Trier Social Stress Test Protocol: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2018Pooled it
- Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses.BMC research notes · 2018Pooled it
- Diet-Induced Weight Loss Has No Effect on Psychological Stress in Overweight and Obese Adults: A Meta-Analysis of Randomized Controlled Trials.Nutrients · 2018Pooled it
- Work-related stress as a cardiovascular risk factor in police officers: a systematic review of evidence.International archives of occupational and environmental health · 2018Pooled it
- Perceived stress and progression of cardiometabolic risk factors among South Asians with prediabetes in a lifestyle intervention trial.Primary care diabetes · 2024Trial
- Sleep Satisfaction May Modify the Association between Metabolic Syndrome and BMI, Respectively, and Occupational Stress in Japanese Office Workers.International journal of environmental research and public health · 2022Trial
- Coping Strategies Influence Cardiometabolic Risk Factors in Chronic Psychological Stress: A Post Hoc Analysis of A Randomized Pilot Study.Nutrients · 2021Trial
- Smoking cessation, metabolic risk behaviors, and stress management over time in a sample of young adult smokers.Translational behavioral medicine · 2021Trial
- Trial
- The Electronic CardioMetabolic Program (eCMP) for Patients With Cardiometabolic Risk: A Randomized Controlled Trial.Journal of medical Internet research · 2016Trial
- Chronic Occupational Stress and Immune-Inflammatory Dysregulation: Mechanisms, Clinical Consequences, Biomarkers and Implications for Occupational Medicine.Diagnostics (Basel, Switzerland) · 2026Review
- Psychological Determinants of the Weight Cycle: A Review of Perceived Stress and Self-Efficacy.Current obesity reports · 2026Review
- Association between perceived stress and metabolic parameters: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2026Review
- The mediating effect of BMI on the increased prevalence of metabolic syndrome among workers with occupational stress.BMC public health · 2026Article
- Cardiometabolic risk mediates the association between perceived stress and learning and memory similarly among Hispanic/Latino and non-Hispanic White individuals.Journal of clinical and experimental neuropsychology · 2026Observational
- Association of work-related stressors, support, and satisfaction with cardiovascular disease incidence among Japanese civil servants: a prospective cohort study.Journal of occupational health · 2026Article
- Association between chronic stress and the epigenome: Exploration of psychological and biological stress.PloS one · 2026Article
- Nonlinear thresholds in lipid-frailty interplay: Precision targets for severe airflow limitation in aging adults.PloS one · 2026Article
- Associations between perceived stress and glycemic measures: gender and age as moderators.BMJ open diabetes research & care · 2025Observational
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic psychosocial stress has been proposed as a risk factor for the development of the metabolic syndrome (MES). This review gives a systematic overview of prospective cohort studies investigating chronic psychosocial stress as a risk factor for incident MES and the individual elements of MES. Thirty-nine studies were included. An association between chronic psychosocial stress and the development of MES was generally supported. Regarding the four elements of MES: i) weight gain: the prospective studies supported etiological roles for relationship stress, perceived stress, and distress, while the studies on work-related stress (WS) showed conflicting results; ii) dyslipidemi: too few studies on psychosocial stress as a risk factor for dyslipidemia were available to draw a conclusion; however, a trend toward a positive association was present; iii) type 2 diabetes mellitus (DM2): prospective studies supported perceived stress and distress as risk factors for the development of DM2 among men, but not among women, while WS was generally not supported as a risk factor among neither men nor women; iv) hypertension: marital stress and perceived stress might have an influence on blood pressure (BP), while no association was found regarding distress. Evaluating WS the results were equivocal and indicated that different types of WS affected the BP differently between men and women. In conclusion, a longitudinal association between chronic psychosocial stress and the development of MES seems present. However, the number of studies with sufficient quality is limited and the design of the studies is substantially heterogeneous.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.