ArticleMolecular biology of the cell2014
The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism.
Article in Molecular biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Genetic Variation in PEAR1, Cardiovascular Outcomes and Effects of Aspirin in a Healthy Elderly Population.Clinical pharmacology and therapeutics · 2020Trial
- Stabilin‑1: An immunoregulatory scavenger receptor in inflammation and tissue homeostasis (Review).Molecular medicine reports · 2026Review
- A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression.Cancer research · 2025Article
- The cellular adaptor GULP1 interacts with ATG14 to potentiate autophagy and APP processing.Cellular and molecular life sciences : CMLS · 2024Article
- SVEP1 is an endogenous ligand for the orphan receptor PEAR1.Nature communications · 2023Article
- Integrative analysis of drug response and clinical outcome in acute myeloid leukemia.Cancer cell · 2022Article
- Planarian EGF repeat-containing genes megf6 and hemicentin are required to restrict the stem cell compartment.PLoS genetics · 2020Article
- Jedi-1 deficiency increases sensory neuron excitability through a non-cell autonomous mechanism.Scientific reports · 2020Article
- Platelet endothelial aggregation receptor-1 regulates bovine muscle satellite cell migration and differentiation via integrin beta-1 and focal adhesion kinase.Cell adhesion & migration · 2019Article
- Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development.The Journal of cell biology · 2019Article
- Stabilin Receptors: Role as Phosphatidylserine Receptors.Biomolecules · 2019Review
- Engulfment signals and the phagocytic machinery for apoptotic cell clearance.Experimental & molecular medicine · 2017Review
- A Study to Investigate the Role ofImmunological disorders & immunotherapy · 2016Article
- Enhanced phagocytic capacity endows chondrogenic progenitor cells with a novel scavenger function within injured cartilage.Osteoarthritis and cartilage · 2016Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
During the development of the peripheral nervous system, the large number of apoptotic neurons generated are phagocytosed by glial precursor cells. This clearance is mediated, in part, through the mammalian engulfment receptor Jedi-1. However, the mechanisms by which Jedi-1 mediates phagocytosis are poorly understood. Here we demonstrate that Jedi-1 associates with GULP, the mammalian homologue of CED-6, an adaptor protein required for phagocytosis mediated by the nematode engulfment receptor CED-1. Silencing GULP or mutating the NPXY motif in Jedi-1, which is required for GULP binding, prevents Jedi-1-mediated phagocytosis. How GULP promotes engulfment is not known. Of interest, we find that Jedi-1-induced phagocytosis requires GULP binding to clathrin heavy chain (CHC). During engulfment, CHC is tyrosine phosphorylated, which is required for Jedi-mediated engulfment. Both phosphoclathrin and actin accumulate around engulfed microspheres. Furthermore, knockdown of CHC in HeLa cells prevents Jedi-1-mediated engulfment of microspheres, and knockdown in glial precursors prevents the engulfment of apoptotic neurons. Taken together, these results reveal that Jedi-1 signals through recruitment of GULP, which promotes phagocytosis through a noncanonical phosphoclathrin-dependent mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.