ArticlePloS one2014
Phenotypic resistance and the dynamics of bacterial escape from phage control.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Death and chemotaxis: Bacterial chemotaxis enables collective escape from phage predation.Science advances · 2026Article
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- Assessing the impact of bacterial heterogeneity on bacteriophage population dynamics.Journal of pharmacokinetics and pharmacodynamics · 2026Article
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- Short-term antagonism between bacteriophages and macrophages decreases with bacteria-phage coevolution.The ISME journal · 2026Article
- Article
- The intestinal environment potentiates bacteriophage adaptation in response to phenotypic resistance inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Characterization and genome analyses of the novel phages targeting extraintestinal Escherichia coli clones ST131 and ST410.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Quantifying phage infectivity from characteristics of bacterial population dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Characterization of Salmonella adaptation in response to phage treatment in broiler chickens.Veterinary research · 2025Article
- Characterization and genome analysis of a novel phage BP15 infecting Vibrio parahaemolyticus.Scientific reports · 2025Article
- Challenges and opportunities of phage therapy forApplied and environmental microbiology · 2024Review
- Phage-host-immune system dynamics in bacteriophage therapy: basic principles and mathematical models.Translational and clinical pharmacology · 2023Review
- Bacteria-phage coevolution with a seed bank.The ISME journal · 2023Article
- A K-17 serotype specific Klebsiella phage JKP2 with biofilm reduction potential.Virus research · 2023Article
- Back to the Roots:Applied and environmental microbiology · 2023Article
- Article
- The Burden of Survivors: How Can Phage Infection Impact Non-Infected Bacteria?International journal of molecular sciences · 2023Review
- Ecology and Evolutionary Biology of Hindering Phage Therapy: The Phage Tolerance vs. Phage Resistance of Bacterial Biofilms.Antibiotics (Basel, Switzerland) · 2023Review
- Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
The canonical view of phage - bacterial interactions in dense, liquid cultures is that the phage will eliminate most of the sensitive cells; genetic resistance will then ascend to restore high bacterial densities. Yet there are various mechanisms by which bacteria may remain sensitive to phages but still attain high densities in their presence - because bacteria enter a transient state of reduced adsorption. Importantly, these mechanisms may be cryptic and inapparent prior to the addition of phage yet result in a rapid rebound of bacterial density after phage are introduced. We describe mathematical models of these processes and suggest how different types of this 'phenotypic' resistance may be elucidated. We offer preliminary in vitro studies of a previously characterized E. coli model system and Campylobacter jejuni illustrating apparent phenotypic resistance. As phenotypic resistance may be specific to the receptors used by phages, awareness of its mechanisms may identify ways of improving the choice of phages for therapy. Phenotypic resistance can also explain several enigmas in the ecology of phage-bacterial dynamics. Phenotypic resistance does not preclude the evolution of genetic resistance and may often be an intermediate step to genetic resistance.
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