ArticlePloS one2014
Impact of hypertension on the association of BMI with risk and age at onset of type 2 diabetes mellitus: age- and gender-mediated modifications.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Urinary extracellular vesicle miRNA signature reflects pancreatic islet stress in type 2 diabetes.Journal of diabetes investigation · 2026Article
- Investigation of the Impact of Body Mass Index in the 20s on Chronic Metabolic Diseases and Their Progression Rate After the Age of 65 Years.Journal of Korean medical science · 2025Article
- Body mass index-defined overweight (but not obese) correlates with better postoperative prognosis in colorectal cancer.Journal of gastrointestinal oncology · 2025Article
- Diabetes Mellitus and Its Risk Factors among Migrant Workers in Kuwait.International journal of environmental research and public health · 2022Article
- The Association Between Body Mass Index and Comorbidity, Quality of Life, and Cognitive Function in the Elderly Population.International journal of community based nursing and midwifery · 2020Article
- Mental and Addictive Disorders and Medical Comorbidities.Current psychiatry reports · 2018Review
- Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study.PloS one · 2017Article
- Prevalence and Risk Factors of Comorbidities among Hypertensive Patients in China.International journal of medical sciences · 2017Article
- Article
- Response to leptin and nitric oxide in blood pressure regulation in humans.American journal of hypertension · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsGiven that BMI correlates with risk of Type 2 diabetes mellitus (T2DM), and that hypertension is a common comorbid condition, we hypothesize that hypertension augments significantly the impact of obesity on T2DM onset.
methodsWe obtained data on T2DM in Kuwaiti natives from Kuwait Health Network Registry. We considered 1339 comorbid individuals with onset of hypertension preceding that of T2DM, and 3496 non-hypertensive individuals but with T2DM. Multiple linear regressions, ANOVA tests, and Cox proportional hazards models were used to quantify the impact of hypertension on correlation of BMI with age at onset and risk of T2DM.
resultsImpact of increasing levels of BMI on age at onset ot T2DM is seen augmented in patients diagnosed with hypertension. We find that the slope of the inverse linear relationship between BMI and onset age of T2DM is much steep in hypertensive patients (-0.69, males and -0.39, females) than in non-hypertensive patients (-0.36, males and -0.17, females). The decline in onset age for an unit increase of BMI is two-fold in males than in females. Upon considering BMI as a categorical variable, we find that while the mean onset age of T2DM in hypertensive patients decreases by as much as 5-12 years in every higher BMI categories, significant decrease in non-hypertensive patients exists only when severely obese. Hazard due to hypertension (against the baseline of non-hypertension and normal weight) increases at least two-fold in every obese category. While males have higher hazard due to hypertension in early adulthood, females have higher hazard in late adulthood.
conclusionPre-existing condition of hypertension augments the association of BMI with Type 2 diabetes onset in both males and females. The presented results provide health professionals directives on the extent of weight-loss required to delay onset of Type 2 diabetes in hypertensive versus non-hypertensive patients.
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