ReviewJournal of perinatology : official journal of the California Perinatal Association2014
End-tidal carbon monoxide and hemolysis.
Review in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
End Tidal Carbon Monoxide (ETCO) : A Tool to Aid Identification of Neonatal Hemolysis
Clinical Value of ETCOc in the Diagnosis and Treatment of ABO Hemolytic Disease of the Newborn
Who cites it
18 citing papers in PubMed.
- The prediction of phototherapy by early postnatal ETCOc in Chinese newborns.BMC pediatrics · 2025Trial
- End-tidal CO corrected for ambient CO risk adjusted phototherapy threshold for the management of neonatal hyperbilirubinemia: a randomized clinical trial.World journal of pediatrics : WJP · 2025Trial
- Hemolysis during and after 21 days of head-down-tilt bed rest.Physiological reports · 2017Trial
- Clinical trial of tin mesoporphyrin to prevent neonatal hyperbilirubinemia.Journal of perinatology : official journal of the California Perinatal Association · 2016Trial
- Can age-specific ETCOc determination predict the need for neonatal phototherapy?Pediatric research · 2026Article
- Age-specific ETCOc measured by non-dispersive infrared spectroscopy predicts neonatal phototherapy.Pediatric research · 2026Article
- Exhaled carbon monoxide: variations due to collection method and physiology.Journal of breath research · 2025Article
- Defining a core breath profile for healthy, non-human primates.Scientific reports · 2024Article
- End-tidal carbon monoxide concentrations measured within 48 hours of birth predict hemolytic hyperbilirubinemia.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Is it time for a precision health approach to the management of newborn hyperbilirubinemia?Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- A "Gold Standard" Test for Diagnosing and Quantifying Hemolysis in Neonates and Infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Reference intervals for end-tidal carbon monoxide of preterm neonates.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Breath Biomarkers in Diagnostic Applications.Molecules (Basel, Switzerland) · 2021Review
- ABO hemolytic disease of the fetus and newborn: thirteen years of data after implementing a universal bilirubin screening and management program.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- A patient with both methemoglobinemia and G6PD deficiency: A therapeutic conundrum.American journal of hematology · 2017Article
- A new method to evaluate macaque health using exhaled breath: A case study ofJournal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Determinants of Carboxyhemoglobin Levels and Relationship with Sepsis in a Retrospective Cohort of Preterm Neonates.PloS one · 2016Article
- Bilirubin production and hour-specific bilirubin levels.Journal of perinatology : official journal of the California Perinatal Association · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemolytic disease in newborns can result from a number of conditions, which can place such infants at an increased risk for the development of severe hyperbilirubinemia. Because the catabolism of heme produces equimolar amounts of carbon monoxide (CO) and bilirubin, measurements of end-tidal breath CO (corrected for ambient CO) or ETCOc can serve as an index of hemolysis as well as of bilirubin production from any cause. Elevated levels of ETCOc have been correlated with blood carboxyhemoglobin levels and thus hemolysis. However, the detection of hemolysis can be a clinically challenging problem in newborns. Here, we describe the importance of determining ETCOc levels and their application in identifying infants at risk for developing hyperbilirubinemia associated with hemolysis and other causes of increased bilirubin production.
Indexed as
Identifiers
24743136What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.