Evidence map›Paper›PMID 24743058›Full record

ReviewCurrent opinion in neurobiology2014

Inhibition downunder: an update from the spinal cord.

Martyn Goulding, Steeve Bourane, Lidia Garcia-Campmany, Antoine Dalet, Stephanie Koch

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. Tonically active interneurons gate motor output inbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Muscle Spasms after Spinal Cord Injury Stem from Changes in Motoneuron Excitability and Synaptic Inhibition, Not Synaptic Excitation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Spinal Basis of Direction Control during Locomotion in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  7. Inhibitory Synaptic Influences on Developmental Motor Disorders.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor Pathways.International journal of molecular sciences · 2021
    Review
  14. Article
  15. Article
  16. The activation of DNeuroscience letters · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. GABAergic inhibition of leg motoneurons is required for normal walking behavior in freely movingProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Martyn GouldingMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: goulding@salk.edu.
Steeve BouraneMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Lidia Garcia-CampmanyMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Antoine DaletMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Stephanie KochMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Funding

Intersectional genetic dissection of spinal circuits processing pain and itchR01NS086372 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GOULDING, MARTYN D, MA, QIUFU · 2013 to 2017
$3.5M
Spinal circuits for mechanical itch and light touchR01NS080586 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GOULDING, MARTYN D · 2013 to 2018
$2.8M
NINDS NIH HHS NS080586NINDS NIH HHS NS086372NINDS NIH HHS R01 NS080586NINDS NIH HHS R01 NS086372
6 · The paper itself

Abstract

Inhibitory neurons in the spinal cord perform dedicated roles in processing somatosensory information and shaping motor behaviors that range from simple protective reflexes to more complex motor tasks such as locomotion, reaching and grasping. Recent efforts examining inhibition in the spinal cord have been directed toward determining how inhibitory cell types are specified and incorporated into the sensorimotor circuitry, identifying and characterizing molecularly defined cohorts of inhibitory neurons and interrogating the functional contribution these cells make to sensory processing and motor behaviors. Rapid progress is being made on all these fronts, driven in large part by molecular genetic and optogenetic approaches that are being creatively combined with neuroanatomical, electrophysiological and behavioral techniques.

Indexed as

AnimalsLocomotionNerve NetNeuronsSpinal CordSynapses

Identifiers

PMID24743058
PMCPMC4059017

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.