Evidence map›Paper›PMID 24742955›Full record

Trial reportOsteoarthritis and cartilage2014

The independent and combined effects of intensive weight loss and exercise training on bone mineral density in overweight and obese older adults with osteoarthritis.

D P Beavers, K M Beavers, R F Loeser, N R Walton, M F Lyles, B J Nicklas, S A Shapses, J J Newman, S P Messier

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Osteoarthritis and cartilage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00381290 (Intensive Diet and Exercise for Arthritis), which is not on this map. Cited by 36 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 9 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00381290 nacompletednot on this map

Intensive Diet and Exercise for Arthritis

TypeinterventionalSponsorWake Forest UniversityRan2006 to 2011Enrolled454ConditionsOsteoarthritisArmsDiet, Exercise
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 9 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Does exercise affect bone mineral density and content when added to a calorie-restricted diet? A systematic review and meta-analysis of controlled clinical trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Pooled it
  5. Pooled it
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  7. The effect of exercise training on osteocalcin, adipocytokines, and insulin resistance: a systematic review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Pooled it
  8. The effects of weight loss approaches on bone mineral density in adults: a systematic review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Pooled it
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  13. Effect of Exercise Modality During Weight Loss on Bone Health in Older Adults With Obesity and Cardiovascular Disease or Metabolic Syndrome: A Randomized Controlled Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
    Trial
  14. Change in Bone Mineral Density During Weight Loss with Resistance Versus Aerobic Exercise Training in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Trial
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  16. Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016
    Trial
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

D P BeaversDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: dbeavers@wakehealth.edu.
K M BeaversSection on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: kbeavers@wakehealth.edu.
R F LoeserSection on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: rloeser@wakehealth.edu.
N R WaltonSection on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: dr.nwalton@gmail.com.
M F LylesSection on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: mlyles@wakehealth.edu.
B J NicklasSection on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: bnicklas@wakehealth.edu.
S A ShapsesDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA. Electronic address: shapses@aesop.rutgers.edu.
J J NewmanDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA. Electronic address: jollajk@wfu.edu.
S P MessierDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA. Electronic address: messier@wfu.edu.
Wake Forest University · USRutgers, The State University of New Jersey · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Intensive Dietary Restriction with Exercise in ArthritisR01AR052528 · NIAMS · WAKE FOREST UNIVERSITY · PI MESSIER, STEPHEN P · 2006 to 2010
$2.9M
NIAMS NIH HHS AR052528NIAMS NIH HHS R01 AR052528NIA NIH HHS P30 AG021332NIA NIH HHS P30-AG21332
6 · The paper itself

Abstract

objectiveTo determine the effects of dietary-induced weight loss (D) and weight loss plus exercise (D + E) compared to exercise alone (E) on bone mineral density (BMD) in older adults with knee osteoarthritis (OA).

designData come from 284 older (66.0 ± 6.2 years), overweight/obese (body mass index (BMI) 33.4 ± 3.7 kg/m2), adults with knee OA enrolled in the Intensive Diet and Exercise for Arthritis (IDEA) study. Participants were randomized to 18 months of walking and strength training (E; n = 95), dietary-induced weight loss targeting 10% of baseline weight (D; n = 88) or a combination of the two (D + E; n = 101). Body weight and composition (DXA), regional BMD, were obtained at baseline and 18 months.

resultsE, D, and D + E groups lost 1.3 ± 4.5 kg, 9.1 ± 8.6 kg and 10.4 ± 8.0 kg, respectively (P < 0.01). Significant treatment effects were observed for BMD in both hip and femoral neck regions, with the D and D + E groups showing similar relative losses compared to E (both P < 0.01). Despite reduced BMD, fewer overall participants had T-scores indicative of osteoporosis after intervention (9 at 18 months vs 10 at baseline). Within the D and D + E groups, changes in hip and femoral neck, but not spine, BMD correlated positively with changes in body weight (r = 0.21 and 0.54 respectively, both P ≤ 0.01).

conclusionsWeight loss via an intensive dietary intervention, with or without exercise, results in bone loss at the hip and femoral neck in overweight and obese, older adults with OA. Although the exercise intervention did not attenuate weight loss-associated reductions in BMD, classification of osteoporosis and osteopenia remained unchanged. CLINICAL TRIAL REGISTRATION NUMBER: NCT00381290.

Indexed as

AgedAged, 80 and overAge FactorsAnalysis of VarianceBody Mass IndexBone DensityCombined Modality TherapyConfidence IntervalsDiet, ReducingExercise TherapyFemaleFollow-Up StudiesHumansMaleObesityOsteoarthritis, KneeBone densityExerciseObesityOsteoarthritisWeight loss

Identifiers

PMID24742955
PMCPMC4051847
OpenAlexW2104861232

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.