Evidence map›Paper›PMID 24742587›Full record

Trial reportAge and ageing2014

The Home-based Older People's Exercise (HOPE) trial: a pilot randomised controlled trial of a home-based exercise intervention for older people with frailty.

Andrew Clegg, Sally Barber, John Young, Steve Iliffe, Anne Forster

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Age and ageing, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03574662 (A Prospective Trial to Evaluate the Utility of Focused Frailty Interventions on Patients With Advanced Heart Failure), which is not on this map. Cited by 61 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03574662 nacompletednot on this mapstarted 2018, after this paper: background citation

A Prospective Trial to Evaluate the Utility of Focused Frailty Interventions on Patients With Advanced Heart Failure

TypeinterventionalSponsorMayo ClinicRan2018 to 2018Enrolled1ConditionsHeart FailureArmsFrailty assessment, Quality of life assessment
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  5. Exercise for preventing falls in older people living in the community.The Cochrane database of systematic reviews · 2019
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  6. Delaying and reversing frailty: a systematic review of primary care interventions.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019
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  8. Depression and frailty in later life: a systematic review.Clinical interventions in aging · 2015
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew CleggAcademic Unit of Elderly Care and Rehabilitation, University of Leeds, Temple Bank House, Bradford Teaching Hospitals NHS Foundation Trust, Duckworth Lane, Bradford, West Yorkshire BD9 6RJ, UK.
Sally BarberBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, West Yorkshire, UK.
John YoungAcademic Unit of Elderly Care and Rehabilitation, Bradford Institute for Health Research, Bradford, West Yorkshire, UK.
Steve IliffeDepartment of Primary Care and Population Health, University College London, London, UK UK Dementias and Neurodegenerative Diseases Research Network, London, UK.
Anne ForsterAcademic Unit of Elderly Care and Rehabilitation, University of Leeds, Bradford, West Yorkshire, UK.

Funding

The Dunhill Medical Trust RCP/DMT 2ND ROUND (2)
6 · The paper itself

Abstract

backgroundfrailty is a state of vulnerability to stressor events. There is uncertainty about the beneficial effects of exercise interventions for older people with frailty. The Home-based Older People's Exercise (HOPE) programme is a 12-week-exercise intervention for older people with frailty designed to improve mobility and function.

methodswe tested feasibility of the HOPE programme in a two arm, assessor blind pilot randomised controlled trial (RCT). Eligibility criteria included living at home and receiving case manager care, being housebound or attending day centres in Bradford, UK. Intervention participants received the HOPE programme; control participants received usual care. Objectives were to gather process, resource, management and scientific data to inform the design of a definitive trial. Primary outcome was mobility, measured using the timed-up-and-go test (TUGT). Secondary outcomes were activities of daily living, health-related quality of life and depression. Participants were stratified by the baseline TUGT score. Randomisation was by the University of Leeds Clinical Trials Research Unit.

resultseighty-four participants were recruited. Forty-five were randomised to intervention and 39 to control. Forty intervention participants and 30 control participants were included in the intention-to-treat analysis. There was a non-significant trend towards a clinically important improved outcome in the intervention group (mean adjusted between-group difference in the TUGT 28.6 s, 95% CI -8.5, 65.9 s). There were no differences in secondary outcomes.

conclusionthe HOPE trial has provided preliminary evidence that the deterioration in mobility experienced by older people with frailty may be reduced through a 12-week-exercise intervention. The pilot trial has provided the necessary data to design a future definitive RCT.Trial registration and date of first participant randomisation.Current Controlled Trials: International Standard Randomised Controlled Trial Number ISRCTN57066881. Date of trial registration 19/05/2010. Date of first participant randomisation 15/07/2010.

Indexed as

Exercise TherapyFrail ElderlyHome Care ServicesActivities of Daily LivingAgedAged, 80 and overAge FactorsAgingDepressionEnglandFeasibility StudiesFemaleGeriatric AssessmentHumansMaleMobility Limitationexercisefrailtyhomeolder peoplephysical activityrandomised controlled trial

Identifiers

PMID24742587
PMCPMC4146519

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.