Evidence map›Paper›PMID 24742463›Full record

ArticleNeuron2014

Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway.

Martin D Haustein, Sebastian Kracun, Xiao-Hong Lu, Tiffany Shih, Olan Jackson-Weaver, Xiaoping Tong, Ji Xu, X William Yang, Thomas J O'Dell, Jonathan S Marvin and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 242 citations in OpenAlex.

  1. Article
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  8. Astrocytic CaNature neuroscience · 2025
    Article
  9. Spontaneous activity of astrocytes is a stochastic functional signal for memory consolidation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  20. Review

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Martin D HausteinDepartment of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1751, USA.
Sebastian KracunDepartment of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1751, USA.
Xiao-Hong LuCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1751, USA.
Tiffany ShihNational Center for Microscopy and Imaging Research and Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Olan Jackson-WeaverDepartment of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1751, USA.
Xiaoping TongDepartment of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1751, USA.
Ji XuDepartment of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1751, USA.
X William YangCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1751, USA.
Thomas J O'DellDepartment of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1751, USA.
Jonathan S MarvinJanelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Mark H EllismanNational Center for Microscopy and Imaging Research and Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Eric A BushongNational Center for Microscopy and Imaging Research and Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Loren L LoogerJanelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Baljit S KhakhDepartment of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1751, USA; Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1751, USA. Electronic address: bkhakh@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of California, San Diego · USHoward Hughes Medical Institute · USJanelia Research Campus · US

Funding

IVEM and Image Analysis ResourceP41GM103412 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2012 to 2019
$17.9M
Functions of astrocyte calcium signaling in the striatumR01NS060677 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHAKH, BALJIT · 2008 to 2018
$4.3M
Astrocyte branchlet dysfunction as an early step in brain disordersDP1MH104069 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHAKH, BALJIT · 2013 to 2017
$3.9M
Conditional Mouse Models: Non-cell-antonomous Toxicities in Huntington's DiseaseR01NS049501 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIANGDONG WILLIAM · 2004 to 2014
$3.8M
CELLULAR NEUROBIOLOGYT32NS007101 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI O'DELL, THOMAS J · 1985 to 2013
$2.2M
New Optical and Genetic Tools to Study Diverse Calcium Signals in AstrocytesR01MH099559 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHAKH, BALJIT · 2013 to 2017
$1.9M
Validating NT17 Dependent Mechanisms in Huntington's Disease SuppressionR01NS074312 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIANGDONG WILLIAM · 2011 to 2014
$1.4M
NIGMS NIH HHS P41 GM103412NIGMS NIH HHS P41GM103412NIMH NIH HHS DP1 MH104069NIMH NIH HHS MH099559NIMH NIH HHS MH104069NIMH NIH HHS R01 MH099559NINDS NIH HHS NS049501NINDS NIH HHS NS060677NINDS NIH HHS NS074312NINDS NIH HHS R01 NS049501NINDS NIH HHS R01 NS060677NINDS NIH HHS R01 NS074312NINDS NIH HHS T32 NS007101
6 · The paper itself

Abstract

The spatiotemporal activities of astrocyte Ca²⁺ signaling in mature neuronal circuits remain unclear. We used genetically encoded Ca²⁺ and glutamate indicators as well as pharmacogenetic and electrical control of neurotransmitter release to explore astrocyte activity in the hippocampal mossy fiber pathway. Our data revealed numerous localized, spontaneous Ca²⁺ signals in astrocyte branches and territories, but these were not driven by neuronal activity or glutamate. Moreover, evoked astrocyte Ca²⁺ signaling changed linearly with the number of mossy fiber action potentials. Under these settings, astrocyte responses were global, suppressed by neurotransmitter clearance, and mediated by glutamate and GABA. Thus, astrocyte engagement in the fully developed mossy fiber pathway was slow and territorial, contrary to that frequently proposed for astrocytes within microcircuits. We show that astrocyte Ca²⁺ signaling functionally segregates large volumes of neuropil and that these transients are not suited for responding to, or regulating, single synapses in the mossy fiber pathway.

Indexed as

Action PotentialsAnimalsAstrocytesCalcium SignalingExcitatory Amino Acid AgentsExcitatory Postsynaptic PotentialsFemaleGABA Agentsgamma-Aminobutyric AcidGlutamic AcidHippocampusIn Vitro TechniquesMaleMiceMice, Inbred C57BLMice, TransgenicExcitatory Amino Acid AgentsGABA Agentsgamma-Aminobutyric AcidGlutamic Acidmetabotropic glutamate receptor 2metabotropic glutamate receptor 3Receptors, GABA-BReceptors, Metabotropic GlutamateSodium Channel Blockers

Identifiers

PMID24742463
PMCPMC4086217
OpenAlexW2058288195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.