ArticleNeuron2014
Selective memory generalization by spatial patterning of protein synthesis.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- Dynamical mechanisms for coordinating long-term working memory based on the precision of spike-timing in cortical neurons.Biological cybernetics · 2026Review
- Plastic Arbor: A modern simulation framework for synaptic plasticity-From single synapses to networks of morphological neurons.PLoS computational biology · 2026Article
- Article
- Computational insights into mRNA and protein dynamics underlying synaptic plasticity rules.Molecular and cellular neurosciences · 2023Review
- The dendritic engram.Frontiers in behavioral neuroscience · 2023Article
- Increased rates of brain protein synthesis during [N1,N2] sleep: L-[1-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Adult-born neurons add flexibility to hippocampal memories.Frontiers in neuroscience · 2023Review
- L-DOPA increases slow-wave sleep duration and selectively modulates memory persistence in older adults.Frontiers in behavioral neuroscience · 2023Article
- Adult neurogenesis acts as a neural regularizer.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Memory consolidation and improvement by synaptic tagging and capture in recurrent neural networks.Communications biology · 2021Article
- Illuminating dendritic function with computational models.Nature reviews. Neuroscience · 2020Review
- Impact of functional synapse clusters on neuronal response selectivity.Nature communications · 2020Article
- Local resources of polyribosomes and SER promote synapse enlargement and spine clustering after long-term potentiation in adult rat hippocampus.Scientific reports · 2019Article
- Cooperation of Genomic and Rapid Nongenomic Actions of Estrogens in Synaptic Plasticity.Molecular neurobiology · 2017Review
- Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites.Cell reports · 2016Article
- Article
- Information processing in the CNS: a supramolecular chemistry?Cognitive neurodynamics · 2015Review
- Computational models in the age of large datasets.Current opinion in neurobiology · 2015Review
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2 authors.
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Abstract
Protein synthesis is crucial for both persistent synaptic plasticity and long-term memory. De novo protein expression can be restricted to specific neurons within a population, and to specific dendrites within a single neuron. Despite its ubiquity, the functional benefits of spatial protein regulation for learning are unknown. We used computational modeling to study this problem. We found that spatially patterned protein synthesis can enable selective consolidation of some memories but forgetting of others, even for simultaneous events that are represented by the same neural population. Key factors regulating selectivity include the functional clustering of synapses on dendrites, and the sparsity and overlap of neural activity patterns at the circuit level. Based on these findings, we proposed a two-step model for selective memory generalization during REM and slow-wave sleep. The pattern-matching framework we propose may be broadly applicable to spatial protein signaling throughout cortex and hippocampus.
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