Evidence map›Paper›PMID 24742373›Full record

ArticleMolecular imaging2014

Ultrasound Detection of Myocardial Ischemic Memory Using an E-Selectin Targeting Peptide Amenable to Human Application.

Xiaoping Leng, Jianjun Wang, Andrew Carson, Xucai Chen, Huili Fu, Susanne Ottoboni, William R Wagner, Flordeliza S Villanueva

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Molecular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Xiaoping Leng *Department of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; Center for Ultrasound Molecular Imaging and Therapeutics and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA; and Depomed, Inc., Newark, CA.
Jianjun Wang *Department of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; Center for Ultrasound Molecular Imaging and Therapeutics and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA; and Depomed, Inc., Newark, CA.
Andrew CarsonDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; Center for Ultrasound Molecular Imaging and Therapeutics and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA; and Depomed, Inc., Newark, CA.
Xucai ChenDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; Center for Ultrasound Molecular Imaging and Therapeutics and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA; and Depomed, Inc., Newark, CA.
Huili FuDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; Center for Ultrasound Molecular Imaging and Therapeutics and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA; and Depomed, Inc., Newark, CA.
Susanne OttoboniDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; Center for Ultrasound Molecular Imaging and Therapeutics and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA; and Depomed, Inc., Newark, CA.
William R WagnerDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; Center for Ultrasound Molecular Imaging and Therapeutics and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA; and Depomed, Inc., Newark, CA.
Flordeliza S VillanuevaDepartment of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; Center for Ultrasound Molecular Imaging and Therapeutics and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA; and Depomed, Inc., Newark, CA.
Harbin Medical University · CN

Funding

Ultrasound-activated microbubbles for targeted siRNA delivery to tumorR01EB016516 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VILLANUEVA, FLORDELIZA S · 2012 to 2015
$2.3M
Targeted Ultrasound Imaging of Angiogenic ReceptorsR01HL077534 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VILLANUEVA, FLORDELIZA S · 2004 to 2007
$1.4M
Development of an In Vivo Stem Cell Tracking Method Using Ultrasound ImagingRC1EB010533 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VILLANUEVA, FLORDELIZA S · 2009 to 2010
$850k
NHLBI NIH HHS R01 HL077534NIBIB NIH HHS R01 EB016516NIBIB NIH HHS RC1 EB010533
6 · The paper itself

Abstract

Vascular endothelial leukocyte adhesion molecules, such as E-selectin, are acutely upregulated in myocardial ischemia/reperfusion and are thus "ischemic memory" biomarkers for recent cardiac ischemia. We sought to develop an ultrasound molecular imaging agent composed of microbubbles (MBs) targeted to E-selectin to enable the differential diagnosis of myocardial ischemia in patients presenting with chest pain of unclear etiology. Biodegradable polymer MBs were prepared bearing a peptide with specific human E-selectin affinity (MB

Identifiers

PMID24742373
PMCPMC4083464
OpenAlexW2143007078

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.