ArticleNano letters2014
Scalable production of highly sensitive nanosensors based on graphene functionalized with a designed G protein-coupled receptor.
Article in Nano letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Dielectrophoresis-Enhanced Graphene Field-Effect Transistors for Nano-Analyte Sensing.ACS applied materials & interfaces · 2025Article
- Next-Gen Point-of-Care Tool for Ultra-Sensitive Detection of Urinary Spermine for Prostate Cancer Diagnosis.ACS sensors · 2025Article
- Detection of IgG Antibodies Against COVID-19 N-Protein by Hybrid Graphene-Nanorod Sensor.Biosensors · 2025Article
- Graphene Biosensor Differentiating Sensitive Interactions between Ribonucleic Acid and Dipeptide Repeats in Liquid-Liquid Phase Separation.ACS applied materials & interfaces · 2025Article
- Strategies for assessing the limit of detection in voltammetric methods: comparison and evaluation of approaches.The Analyst · 2024Article
- Addressing Signal Drift and Screening for Detection of Biomarkers with Carbon Nanotube Transistors.ACS nano · 2024Article
- Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays.Science advances · 2023Article
- Scalable graphene sensor array for real-time toxins monitoring in flowing water.Nature communications · 2023Article
- Protein Design: From the Aspect of Water Solubility and Stability.Chemical reviews · 2022Review
- Article
- Mathematical Modeling for an MTT Assay in Fluorine-Containing Graphene Quantum Dots.Nanomaterials (Basel, Switzerland) · 2022Article
- Graphene for Nanobiosensors and Nanobiochips.Advances in experimental medicine and biology · 2022Article
- Graphene-Based Nanocomposites: Synthesis, Mechanical Properties, and Characterizations.Polymers · 2021Review
- Tunable infrared metamaterial-based biosensor for detection of hemoglobin and urine using phase change material.Scientific reports · 2021Article
- Gold nanoparticle-mediated non-covalent functionalization of graphene for field-effect transistors.Nanoscale advances · 2021Article
- The C-terminus of the mu opioid receptor is critical in G-protein interaction as demonstrated by a novel graphene biosensor.IEEE sensors journal · 2021Article
- Detection of an IL-6 Biomarker Using a GFET Platform Developed with a Facile Organic Solvent-Free Aptamer Immobilization Approach.Sensors (Basel, Switzerland) · 2021Article
- An integrated microfluidic platform for selective and real-time detection of thrombin biomarkers using a graphene FET.The Analyst · 2020Article
- MoS2d materials · 2020Article
- Nanosensors for diagnosis with optical, electric and mechanical transducers.RSC advances · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
We have developed a novel, all-electronic biosensor for opioids that consists of an engineered μ-opioid receptor protein, with high binding affinity for opioids, chemically bonded to a graphene field-effect transistor to read out ligand binding. A variant of the receptor protein that provided chemical recognition was computationally redesigned to enhance its solubility and stability in an aqueous environment. A shadow mask process was developed to fabricate arrays of hundreds of graphene transistors with average mobility of ∼1500 cm(2) V(-1) s(-1) and yield exceeding 98%. The biosensor exhibits high sensitivity and selectivity for the target naltrexone, an opioid receptor antagonist, with a detection limit of 10 pg/mL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.