SynthesisCritical care (London, England)2014
A systematic review of therapeutic hypothermia for adult patients following traumatic brain injury.
Synthesis in Critical care (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective, Interventional Study Evaluating the Feasibility and Safety of the Esophageal Cooling Device in 15 Patients Suffering From Traumatic Brain Injury and Treated With Targeted Temperature Management
Effect of a Novel Cooling Device on Brain Temperature
Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- Therapeutic hypothermia in patients with traumatic brain injury: an umbrella review.BMC neurology · 2025Pooled it
- Therapeutic Hypothermia Compared with Normothermia in Adults with Traumatic Brain Injury; Functional Outcome, Mortality, and Adverse Effects: A Systematic Review and Meta-Analysis.Neurocritical care · 2024Pooled it
- A meta-analysis of the effects of therapeutic hypothermia in adult patients with traumatic brain injury.Critical care (London, England) · 2019Pooled it
- Hypothermia for traumatic brain injury.The Cochrane database of systematic reviews · 2017Pooled it
- Efficacy and Safety of a Nasopharyngeal Catheter for Selective Brain Cooling in Patients with Traumatic Brain Injury: A Prospective, Non-randomized Pilot Study.Neurocritical care · 2021Trial
- Esophageal Temperature Management in Patients Suffering from Traumatic Brain Injury.Therapeutic hypothermia and temperature management · 2019Trial
- Mortality Risk Stratification After Traumatic Brain Injury and Hazard of Death With Titrated Hypothermia in the Eurotherm3235Trial.Critical care medicine · 2017Trial
- Therapeutic Hypothermia Reduces Intracranial Pressure and Partial Brain Oxygen Tension in Patients with Severe Traumatic Brain Injury: Preliminary Data from the Eurotherm3235 Trial.Therapeutic hypothermia and temperature management · 2015Trial
- Therapeutic Hypothermia in Traumatic Brain Injury: Should We Reheat the debate or Let it Cool Down?Neurocritical care · 2024Article
- Perioperative Hypothermia in Surgical Patients: A Retrospective Cohort Analysis at a Busy District General Hospital.Cureus · 2024Article
- Clinical Insights and Future Directions in Hypothermia for Severe Traumatic Brain Injury: A Narrative Review.Journal of clinical medicine · 2024Review
- Selective head cooling in the acute phase of concussive injury: a neuroimaging study.Frontiers in neurology · 2023Article
- Therapeutic hypothermia alleviates myocardial ischaemia-reperfusion injury by inhibiting inflammation and fibrosis via the mediation of the SIRT3/NLRP3 signalling pathway.Journal of cellular and molecular medicine · 2022Article
- Hypothermia Induced Impairment of Platelets: Assessment With Multiplate vs. ROTEM-AnFrontiers in physiology · 2022Article
- Prevention and management of perioperative hypothermia in adult elective surgical patients: A systematic review.Annals of medicine and surgery (2012) · 2021Review
- Topical Neck Cooling Prolongs Survival of Rats with Intra-Abdominal Feculent Sepsis by Activation of the Vagus Nerve.International journal of molecular sciences · 2021Article
- Additive Protective Effects of Delayed Mild Therapeutic Hypothermia and Antioxidants on PC12 Cells Exposed to Oxidative Stress.Therapeutic hypothermia and temperature management · 2021Article
- Selective head-neck cooling after concussion shortens return-to-play in ice hockey players.Concussion (London, England) · 2021Article
- An overview of management of intracranial hypertension in the intensive care unit.Journal of anesthesia · 2020Review
- Therapeutic hypothermia for pediatric refractory status epilepticus May Ameliorate post-status epilepticus epilepsy.Biomedical journal · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
introductionResearch into therapeutic hypothermia following traumatic brain injury has been characterised by small trials of poor methodological quality, producing variable results. The Cochrane review, published in 2009, now requires updating. The aim of this systematic review is to assess the effectiveness of the application of therapeutic hypothermia to reduce death and disability when administered to adult patients who have been admitted to hospital following traumatic brain injury.
methodsTwo authors extracted data from each trial. Unless stated in the trial report, relative risks and 95% confidence intervals (CIs) were calculated for each trial. We considered P < 0 · 05 to be statistically significant. We combined data from all trials to estimate the pooled risk ratio (RR) with 95% confidence intervals for death, unfavourable outcome, and pneumonia. All statistical analyses were performed using RevMan 5.1 (Cochrane IMS, Oxford, UK) and Stata (Intercooled Version 12.0, StataCorp LP). Pooled RRs were calculated using the Mantel-Haenszel estimator. The random effects model of DerSimonian and Laird was used to estimate variances for the Mantel-Haenszel and inverse variance estimators.
resultsTwenty studies are included in the review, while 18 provided mortality data. When the results of 18 trials that evaluated mortality as one of the outcomes were statistically aggregated, therapeutic hypothermia was associated with a significant reduction in mortality and a significant reduction in poor outcome. There was a lack of statistical evidence for an association between use of therapeutic hypothermia and increased onset of new pneumonia.
conclusionsIn contrast to previous reviews, this systematic review found some evidence to suggest that therapeutic hypothermia may be of benefit in the treatment of traumatic brain injury. The majority of trials were of low quality, with unclear allocation concealment. Low quality trials may overestimate the effectiveness of hypothermia treatment versus standard care. There remains a need for more, high quality, randomised control trials of therapeutic hypothermia after traumatic brain injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.