ArticleBMC geriatrics2014
Immunosenescence in the nursing home elderly.
Article in BMC geriatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Efficacy of PD-1 & PD-L1 inhibitors in older adults: a meta-analysis.Journal for immunotherapy of cancer · 2018Pooled it
- Longitudinal humoral and memory B-cell responses to repeated SARS-CoV-2 vaccination in long-term care facilities residents.Immunity & ageing : I & A · 2026Article
- Immunotherapy: should we worry about immunosenescence?Ageing and cancer research & treatment · 2024Article
- Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons.Immunity & ageing : I & A · 2022Article
- Modeling of nursing care-associated airborne transmission of SARS-CoV-2 in a real-world hospital setting.GeroScience · 2022Article
- Contemporary nutrition-based interventions to reduce risk of infection among elderly long-term care residents: A scoping review.PloS one · 2022Article
- Influence of nutritional status on clinical outcomes among hospitalized patients with COVID-19.Clinical nutrition ESPEN · 2021Article
- Nutritional screening based on objective indices at admission predicts in-hospital mortality in patients with COVID-19.Nutrition journal · 2021Observational
- Food Access, Diet Quality, and Nutritional Status of Older Adults During COVID-19: A Scoping Review.Frontiers in public health · 2021Article
- Could nutritional and functional status serve as prognostic factors for COVID-19 in the elderly?Medical hypotheses · 2020Article
- Immune Checkpoint Blockade for Advanced NSCLC: A New Landscape for Elderly Patients.International journal of molecular sciences · 2019Review
- Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome.Frontiers in immunology · 2018Review
- Serum C-Reactive Protein and Congestive Heart Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents.The Journal of infectious diseases · 2017Article
- Increased plasma concentrations of interleukin 35 in patients with coronary artery disease.Archives of medical science : AMS · 2017Article
- Circulating muramyl dipeptide is negatively associated with interleukin-10 in the frail elderly.Inflammation · 2015Article
- An Introduction to Automated Flow Cytometry Gating Tools and Their Implementation.Frontiers in immunology · 2015Review
- Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents.PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTo describe T-cell and natural killer (NK) cell phenotypes within nursing home elderly.
methodsNursing home elderly were recruited from four nursing homes in Hamilton, Ontario between September 2010 and December 2011. Healthy adults were recruited from McMaster University between September 2011 and December 2011. Nursing home elderly ≥65 years were eligible; those on immunosuppressive medications were excluded. Healthy adults ≥18-64 years were eligible. CD8+ and CD4+ T-cells% and their subsets, T-regs% and NK cell subset% were compared between the nursing home elderly and healthy adults.
results262 nursing home elderly were enrolled; median age 87 years and 81% were female. 16 healthy adults were enrolled; median age 31 and 50% were female. There was no significant difference between CD8+ T-cell% in nursing home and healthy adults (median 17.1 versus 18.0, p = 0.56), however there were fewer naïve CD8 + T-cell% (median 0.9 versus 5.2, p < 0.001), more terminally differentiated CD8 + T-cell% (median 7.3 versus 4.1, p = 0.004) and more senescent T-cell% (median 5.3 versus 3.1, p = 0.04) in the nursing home elderly. There were more CD4+ T-cell% in the nursing home elderly compared to healthy adults (median 45.5 versus 37.1, p = 0.001). Nursing home elderly had a higher CD4+/CD8+ ratio than healthy adults (2.6 versus 1.9, p = 0.048), higher T-reg% (median 1.8 versus 0.8, p < 0.001) and increased mature NK cell% (median 12.1 versus 5.4, p = 0.001) compared to healthy adults.
conclusionDifferences in naïve CD8+ T-cells, terminally differentiated and senescent CD8+ T-cells, T-regs and NK cell subsets were similar to studies involving community dwelling elderly. In contrast, the CD4+/CD8+ ratio was higher in nursing home elderly.
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