ArticleBMC pediatrics2014
Successful control of a neonatal outbreak caused mainly by ST20 multidrug-resistant SHV-5-producing Klebsiella pneumoniae, Greece.
Article in BMC pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Clinical and molecular characterizations of carbapenem-resistant Klebsiella pneumoniae among children with bloodstream infections in Beijing, China.BMC infectious diseases · 2026Article
- Prospective genomic and epidemiologic surveillance of Klebsiella pneumoniae in a tertiary NICU.Antimicrobial resistance and infection control · 2026Article
- Carriage of hypervirulent and ESBL-producingApplied and environmental microbiology · 2026Article
- Next generation ESKAPE-E superbugs: identifying transmissible locus of stress tolerance and antibiotic resistance in pandemic bacterial lineages.npj antimicrobials and resistance · 2025Article
- Antibiotic resistance and novel Sequence Types ofCurrent research in microbial sciences · 2025Article
- Chromosomal integration and plasmid fusion occurring in ST20 carbapenem-resistantEmerging microbes & infections · 2024Article
- Longitudinal genomic surveillance of a UK intensive care unit shows a lack of patient colonisation by multi-drug-resistant Gram-negative bacterial pathogens.Microbial genomics · 2024Article
- Genomic characterization of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) strains circulating in three university hospitals in Northern Italy over three years.Antimicrobial resistance and infection control · 2024Article
- Environmental contamination across multiple hospital departments with multidrug-resistant bacteria pose an elevated risk of healthcare-associated infections in Kenyan hospitals.Antimicrobial resistance and infection control · 2023Article
- Geno- and Phenotypic Characteristics of aMicroorganisms · 2022Article
- Occurrence and Characteristics of ESBL- and Carbapenemase- ProducingMicroorganisms · 2022Article
- Large-Scale Genomic Epidemiology of Klebsiella pneumoniae Identified Clone Divergence with Hypervirulent Plus Antimicrobial-Resistant Characteristics Causing Within-Ward Strain Transmissions.Microbiology spectrum · 2022Article
- Antimicrobial Resistance Genes in ESBL-ProducingAntibiotics (Basel, Switzerland) · 2021Article
- Successful control of an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae ST307 outbreak in a neonatal intensive care unit.BMC infectious diseases · 2020Article
- FecalFrontiers in microbiology · 2020Article
- Effect of camera monitoring and feedback along with training on hospital infection rate in a neonatal intensive care unit.Annals of clinical microbiology and antimicrobials · 2019Article
- Exploring the phenotype and genotype of multi-drug resistant Klebsiella pneumoniae harbouring blaAnnals of clinical microbiology and antimicrobials · 2019Article
- Identification, molecular characterization, and structural analysis of the blaThe Journal of antibiotics · 2019Article
- Characterization of an Outbreak of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae in a Neonatal Intensive Care Unit in Italy.Microbial drug resistance (Larchmont, N.Y.) · 2018Article
- Characteristics of carbapenemase-producingExperimental and therapeutic medicine · 2017Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtended spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-Kp) infection can cause significant morbidity and mortality in neonates. We investigated a nosocomial ESBL-Kp outbreak in a neonatal intensive care unit (NICU) of the University Hospital of Larissa (UHL), Central Greece.
methodsA total of sixty-four ESBL-Kp were studied; twenty six isolates were recovered from the NICU and were compared with thirty-eight randomly selected isolates from different wards of the hospital during the period March- December 2012. All isolates were characterized by antimicrobial susceptibility testing, ESBL-production by double-disk synergy test, molecular typing using BOX-PCR, whereas selected isolates were further characterized by beta lactamase and virulence gene content, multilocus sequence typing and phylogenetic analysis. All neonates affected by ESBL-Kp were put under strict contact isolation, along with appropriate infection control measures.
resultsThe outbreak strain of ST20 multidrug-resistant SHV-5-producing K. pneumoniae was identified in all infected (n = 13) and three colonized neonates. A novel ST (ST1114) was also identified among SHV-5 producers (n = 10) recovered from nine colonized infants, but it was not related with ST20. Both STs were identified only in the NICU and not in other wards of the hospital. No ESBL-Kp were isolated from the hands of the nursing staff and the environment. Although we were not able to identify the source of the outbreak, no ESBL-Kp were isolated in the NICU after this period and we assumed that the outbreak was successfully controlled. All neonates received parenteral nutrition and most of them were delivered by caesarean section and showed low gestational age (<32 weeks) and low birth weights (<1500 g).
conclusionAccording to our knowledge, this is the first description of an outbreak of multidrug-resistant SHV-5 producing K. pneumoniae assigned to ST20.
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