ReviewJournal of immunology research2014
Periodontitis as a risk factor of atherosclerosis.
Review in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.
- Is There Any Association Between Neurodegenerative Diseases and Periodontitis? A Systematic Review.Frontiers in aging neuroscience · 2021Pooled it
- Periodontitis and diabetes: a bidirectional link.Acta diabetologica · 2026Review
- Combined Influence of Dental Caries and Periodontal Disease on Ischemic Stroke Risk.Neurology open access · 2025Article
- Detecting Oral Bacteria in Abdominal Aorta Atherosclerotic Plaques-How Far Can They Go?Medicina (Kaunas, Lithuania) · 2025Article
- Oral Dysbiosis Is Associated with the Pathogenesis of Aortic Valve Diseases.Microorganisms · 2025Article
- Porphyromonas gingivalis induced DNA oxidative stress damage by iron overload to deplete CTCF expression and prevent osteogenic differentiation of periodontal ligament stem cells.Journal of molecular histology · 2025Article
- Antioxidant and Anti-Inflammatory Effects of Bioactive Compounds in Atherosclerosis.International journal of molecular sciences · 2025Review
- Fourier transform infrared spectroscopy and machine learning for Porphyromonas gingivalis detection in oral bacteria.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- The impact of metabolic disorders on management of periodontal health in children.Pediatric discovery · 2024Article
- Effect of non-surgical periodontal therapy on CD14 + CD16+ monocyte counts in peripheral blood samples: a clinical interventional study.BMC oral health · 2024Article
- Association of Dental Infections with Intracranial Atherosclerotic Stenosis.Cerebrovascular diseases (Basel, Switzerland) · 2024Article
- The interaction between oral microbiota and gut microbiota in atherosclerosis.Frontiers in cardiovascular medicine · 2024Review
- Article
- The oral microbiome in the pathophysiology of cardiovascular disease.Nature reviews. Cardiology · 2023Review
- Immunological Role of Toll-Like Receptor Markers (TLR2 and TLR4) in Patients withArchives of Razi Institute · 2023Article
- Chronic Kidney Disease and Periodontitis Interplay-A Narrative Review.International journal of environmental research and public health · 2023Review
- Patients with periodontitis are at a higher risk of stroke: A Taiwanese cohort study.Journal of the Chinese Medical Association : JCMA · 2022Article
- Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review.Biomedicines · 2022Review
- Oral microbiota in human systematic diseases.International journal of oral science · 2022Review
- Effect of periodontal disease on oxidative stress markers in patients with atherosclerosis.Clinical oral investigations · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last two decades, the amount of evidence corroborating an association between dental plaque bacteria and coronary diseases that develop as a result of atherosclerosis has increased. These findings have brought a new aspect to the etiology of the disease. There are several mechanisms by which dental plaque bacteria may initiate or worsen atherosclerotic processes: activation of innate immunity, bacteremia related to dental treatment, and direct involvement of mediators activated by dental plaque and involvement of cytokines and heat shock proteins from dental plaque bacteria. There are common predisposing factors which influence both periodontitis and atherosclerosis. Both diseases can be initiated in early childhood, although the first symptoms may not appear until adulthood. The formation of lipid stripes has been reported in 10-year-old children and the increased prevalence of obesity in children and adolescents is a risk factor contributing to lipid stripes development. Endothelium damage caused by the formation of lipid stripes in early childhood may lead to bacteria penetrating into blood circulation after oral cavity procedures for children as well as for patients with aggressive and chronic periodontitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.