ArticleJournal of immunology research2014
Acquired hemophilia A: a frequently overlooked autoimmune hemorrhagic disorder.
Article in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Rituximab for eradicating inhibitors in people with acquired haemophilia A.The Cochrane database of systematic reviews · 2021Pooled it
- Rituximab for eradicating inhibitors in people with acquired haemophilia A.The Cochrane database of systematic reviews · 2016Pooled it
- Real-world Diagnosis and Testing of Acquired Hemophilia A in Japan: A Web-based Physician Survey.Internal medicine (Tokyo, Japan) · 2026Observational
- Factor VIII Inhibitors in the Context of Renal Cell Carcinoma and Hemophilia A: A Tale of Two Causes.Cureus · 2025Article
- Genetics and Epigenetics in Acquired Hemophilia A: From Bench to Bedside.Current issues in molecular biology · 2024Review
- Real-world use of recombinant porcine sequence factor VIII in the treatment of acquired hemophilia A: EU PASS.Therapeutic advances in hematology · 2024Article
- Level of Awareness of Acquired Hemophilia A Among Physicians in Türkiye: A Survey StudyTurkish journal of haematology : official journal of Turkish Society of Haematology · 2023Article
- Review
- Acquired haemophilia A associated to autoimmune thyroiditis and pangastritis.BMJ case reports · 2022Article
- Recognition of the unique bleeding pattern and laboratory findings in acquired haemophilia A facilitates prompt treatment of a life-threatening disorder.BMJ case reports · 2021Article
- Acquired Hemophilia A and urothelial carcinoma.Journal of community hospital internal medicine perspectives · 2021Article
- Article
- Article
- Acquired Factor XI Deficiency with Lupus Anticoagulant in a Pregnant Woman Diagnosed by the Eruptions and Pain in Fingers.Case reports in obstetrics and gynecology · 2020Article
- [Post-transplantation lymphoproliferative disorder accompanies acquired hemophilia after haploid hematopoietic stem cell transplantation in a pediatric AML patient: a case report and literature review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2019Review
- Acquired hemophilia A presenting as progressive intra-abdominal hemorrhage, muscle hemorrhage and hemothorax postpartum: A case report and literature review.Experimental and therapeutic medicine · 2019Article
- Acquired Hemophilia of Unknown Etiology in an Elderly Man: Case Report.The American journal of case reports · 2018Article
- Acquired Hemophilia A: Experience of a Tertiary Care Institute from North India.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2018Article
- Acquired von Willebrand Syndrome Complicating Nephrotic Syndrome: A Case of a Patient With Membranous Nephropathy.Clinical medicine insights. Case reports · 2018Article
- Disappearance of Acquired Hemophilia A after Complete Remission in a Multiple Myeloma Patient.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acquired hemophilia A (AHA) is a rare hemorrhagic disease in which autoantibodies against coagulation factor VIII- (FVIII-) neutralizing antibodies (inhibitors) impair the intrinsic coagulation system. As the inhibitors developed in AHA are autoantibodies, the disease may have an autoimmune cause and is often associated with autoimmune disease. Although acute hemorrhage associated with AHA may be fatal and is costly to treat, AHA is often unrecognized or misdiagnosed. AHA should thus be considered in the differential diagnosis particularly in postpartum women and the elderly with bleeding tendency or prolonged activated partial thromboplastin time. Cross-mixing tests and measurement of FVIII-binding antibodies are useful to confirm AHA diagnosis. For treatment of acute hemorrhage, hemostatic therapy with bypassing agents should be provided. Unlike in congenital hemophilia A with inhibitors, in which immune tolerance induction therapy using repetitive infusions of high-dose FVIII concentrates is effective for inhibitor eradication, immune tolerance induction therapy has shown poor efficacy in treating AHA. Immunosuppressive treatment should thus be initiated to eradicate inhibitors as soon as the diagnosis of AHA is confirmed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.