ArticleJournal of immunology research2014
The robust and modulated biomarker network elicited by the Plasmodium vivax infection is mainly mediated by the IL-6/IL-10 axis and is associated with the parasite load.
Article in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between interleukin-2 cytokine levels and Plasmodium infections: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Interleukin-5 levels in relation to malaria severity: a systematic review.Malaria journal · 2023Pooled it
- Impact of NLRP1 Met1154Val and IL1B variants on gestational malaria: an unexplored role of NLRP1 in inflammasome activation by Plasmodium spp.The Journal of pathology · 2025Article
- Asymptomatic vivax malaria is associated with an IFN-γ-program on adaptive immunity.Journal of translational medicine · 2025Article
- IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria.PLoS neglected tropical diseases · 2022Article
- HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria.Scientific reports · 2022Article
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- Inflammatory cytokine responses in children with asymptomatic malaria infection living in rural, semi-urban and urban areas in south-eastern Gabon.Clinical and experimental immunology · 2021Article
- Correlating Fibrinogen Consumption and Profiles of Inflammatory Molecules in Human Envenomation's byFrontiers in immunology · 2020Article
- Increased platelet distribution width and reduced IL-2 and IL-12 are associated with thrombocytopenia in Plasmodium vivax malaria.Memorias do Instituto Oswaldo Cruz · 2020Article
- Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria.PLoS neglected tropical diseases · 2019Article
- Plasma cytokine profiles associated withAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2019Article
- An Immunological Stairway to Severe Tissue Complication Assembly inFrontiers in immunology · 2019Article
- Plasma Eicosanoid Profile inFrontiers in immunology · 2019Article
- Malaria in India: The Need for New Targets for Diagnosis and Detection of Plasmodium vivax.Proteomics. Clinical applications · 2018Review
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- Molecular and immunological analyses of confirmed Plasmodium vivax relapse episodes.Malaria journal · 2017Article
- On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease.Malaria journal · 2017Article
- Association of TLR variants with susceptibility to Plasmodium vivax malaria and parasitemia in the Amazon region of Brazil.PloS one · 2017Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have shown that the inflammatory process, including the biomarker production, and the intense activation of innate immune responses are greater in the malaria caused by Plasmodium vivax than other species. Here, we examined the levels of serum biomarkers and their interaction during acute malaria. MATERIAL AND
methodsBlood samples were collected from P. vivax-infected patients at admission and from healthy donors. Levels of serum biomarkers were measured by Cytometric Bead Assay or ELISA.
resultsP. vivax infection triggered the production of both inflammatory and regulatory biomarkers. Levels of IL-6, CXCL-8, IFN-γ, IL-5, and IL-10 were higher in P. vivax-infected patients than in healthy donors. On the other hand, malaria patients produced lower levels of TNF-α, IL-12p70, and IL-2 than healthy individuals. While the levels of IL-10 and IL-6 were found independent on the number of malaria episodes, higher levels of these cytokines were seen in patients with higher parasite load.
conclusionA mixed pattern of proinflammatory and regulatory biomarkers is produced in P. vivax malaria. Analysis of biomarker network suggests that IL-10 and IL-6 are a robust axis in malaria patients and that this interaction seems to be associated with the parasite load.
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