Evidence map›Paper›PMID 24741584›Full record

ArticleJournal of immunology research2014

Gαs protein expression is an independent predictor of recurrence in prostate cancer.

Lijuan Wang, Guihua Jin, Chenchen He, Xijing Guo, Xia Zhou, Meng Li, Xia Ying, Le Wang, Huili Wu, Qing Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lijuan WangDepartment of Medical Oncology, The First Affiliated Hospital, Xi'an Jiao Tong University of Medical College, Xi'an 710061, China.
Guihua JinDepartment of Medical Oncology, The First Affiliated Hospital, Xi'an Jiao Tong University of Medical College, Xi'an 710061, China.
Chenchen HeDepartment of Medical Oncology, The First Affiliated Hospital, Xi'an Jiao Tong University of Medical College, Xi'an 710061, China.
Xijing GuoDepartment of Medical Oncology, The First Affiliated Hospital, Xi'an Jiao Tong University of Medical College, Xi'an 710061, China.
Xia ZhouDepartment of Medical Oncology, The First Affiliated Hospital, Xi'an Jiao Tong University of Medical College, Xi'an 710061, China.
Meng LiDepartment of Medical Oncology, The First Affiliated Hospital, Xi'an Jiao Tong University of Medical College, Xi'an 710061, China.
Xia YingDepartment of Medical Oncology, The First Affiliated Hospital, Xi'an Jiao Tong University of Medical College, Xi'an 710061, China.
Le WangDepartment of Medical Oncology, The First Affiliated Hospital, Xi'an Jiao Tong University of Medical College, Xi'an 710061, China.
Huili WuDepartment of Medical Oncology, The First Affiliated Hospital, Xi'an Jiao Tong University of Medical College, Xi'an 710061, China.
Qing ZhuDepartment of Medical Oncology, The First Affiliated Hospital, Xi'an Jiao Tong University of Medical College, Xi'an 710061, China.
Xi'an Medical University · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundT393C polymorphism in the gene GNAS1, which encodes the G-protein alpha s subunit (Gαs) of heterotrimeric G protein, is significantly associated with the clinical outcome of patients suffering from several cancers. However, studies on the role and protein expression of Gαs subunit in prostate cancer were still unavailable.

methodsThe immunohistochemical staining was used to assess Gαs expression through tissue microarray procedure of 56 metastatic PCas, 291 localized PCas, and 67 benign hyperplasia (BPH). Gαs expression was semiquantitatively scored and evaluated the correlation with pathologic parameters and biochemical recurrence of prostate-specific antigen (PSA).

resultsGαs expression was localized in nuclear and cytoplasm in prostate cancer cells and downregulated in metastatic PCa compared to localized PCa and BPH (P < 0.001). Gαs was inversely associated with PSA level and Gleason scores; patients with low expression of Gαs had adverse clincopathological features. In multivariable Cox regression analysis, high Gαs expression and Gleason scores were independent predictors of both PSA progression-free and overall survival.

conclusionsGαs down-expression is associated with adverse pathologic features and clinical PSA biochemical recurrence of prostate cancer. Gαs is an independent predictor to help determine the risk of PSA progression and death.

Indexed as

AgedAged, 80 and overGene ExpressionGTP-Binding Protein alpha Subunits, GsHumansMaleMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingPrognosisProstatic NeoplasmsGTP-Binding Protein alpha Subunits, Gs

Identifiers

PMID24741584
PMCPMC3988704
OpenAlexW2043330995

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.