ReviewJournal of immunology research2014
Revisiting the molecular mechanism of neurological manifestations in antiphospholipid syndrome: beyond vascular damage.
Review in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Clinical features and factors associated with outcomes of antibody-negative autoimmune encephalitis in patients requiring intensive care.Critical care (London, England) · 2025Article
- The Spectrum of Movement Disorders Associated with Systemic Lupus Erythematosus.Current neurology and neuroscience reports · 2024Review
- Central nervous system manifestations in rheumatic diseases.Rheumatology international · 2024Review
- Dancing with disorder: chorea - an unusual and neglected manifestation of antiphospholipid syndrome.Lupus science & medicine · 2024Article
- Status dystonicus in adult patients with anti-N-methyl-D-aspartate-acid receptor encephalitis.Journal of neurology · 2023Article
- Proliferative Vasculopathy Associated With Antiphospholipid Antibodies in Patients With Neurological Symptoms.Frontiers in medicine · 2022Article
- Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms.Journal of neuroinflammation · 2021Review
- β2 glycoprotein I participates in phagocytosis of apoptotic neurons and in vascular injury in experimental brain stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- The Significance of Vascular Pathogenesis in the Examination of Corticobasal Syndrome.Frontiers in aging neuroscience · 2021Review
- Adrenal Hemorrhage in a Patient Anticoagulated with Apixaban with Antiphospholipid Syndrome.Cureus · 2019Article
- Stroke presenting with an isolated foot drop in a patient with antiphospholipid syndrome: an uncommon clinical entity.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Reversible Parkinsonism and Multiple Cerebral Infarctions after Pulmonary Endarterectomy in a Patient with Antiphospholipid Syndrome.Internal medicine (Tokyo, Japan) · 2018Article
- Antiphospholipid Syndrome and the Neurologist: From Pathogenesis to Therapy.Frontiers in neurology · 2018Review
- Corticobasal Syndrome Associated with Antiphospholipid Syndrome Secondary to Systemic Lupus Erythematosus.Case reports in neurological medicine · 2018Article
- Autonomic neuropathy-in its many guises-as the initial manifestation of the antiphospholipid syndrome.Immunologic research · 2017Article
- Immunotherapies for Neurological Manifestations in the Context of Systemic Autoimmunity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Current treatment of antiphospholipid syndrome: lights and shadows.Nature reviews. Rheumatology · 2015Review
- Movement disorders in systemic lupus erythematosus and antiphospholipid syndrome--a video presentation.BMJ case reports · 2015Article
- Relation of antiphospholipid antibodies to postmortem brain infarcts in older people.Circulation · 2015Article
- Chorea as a Non-Thrombotic Manifestation in an Adolescent with Systemic Lupus Erythematosus, Antiphospholipid Syndrome and Heterozygous Prothrombin G20210A Gene Mutation: A Case Report.Case reports in neurologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antiphospholipid syndrome (APS) is a multiorgan disease often affecting the central nervous system (CNS). Typically, neurological manifestations of APS include thrombosis of cerebral vessels leading to stroke and requiring prompt initiation of treatment with antiplatelet drugs or anticoagulant therapy. In these cases, alterations of the coagulation system at various levels caused by multiple effects of antiphospholipid antibodies (aPL) have been postulated to explain the vascular damage to the CNS in APS. However, several nonvascular neurological manifestations of APS have progressively emerged over the past years. Nonthrombotic, immune-mediated mechanisms altering physiological basal ganglia function have been recently suggested to play a central role in the pathogenesis of these manifestations that include, among others, movement disorders such as chorea and behavioral and cognitive alterations. Similar clinical manifestations have been described in other autoimmune CNS diseases such as anti-NMDAR and anti-VGCK encephalitis, suggesting that the spectrum of immune-mediated basal ganglia disorders is expanding, possibly sharing some pathophysiological mechanisms. In this review, we will focus on thrombotic and nonthrombotic neurological manifestations of APS with particular attention to immune-mediated actions of aPL on the vascular system and the basal ganglia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.