ArticleJournal of immunology research2014
Obesity and cytokines in childhood-onset systemic lupus erythematosus.
Article in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review.Frontiers in immunology · 2020Pooled it
- Changes in Cholinesterase Activity in Blood of Adolescent with Metabolic Syndrome after Supplementation with Extract fromBioMed research international · 2018Trial
- Body Weight-Related Differences in Adipokines and Inflammatory Markers Among Women with Systemic Lupus Erythematosus.Journal of inflammation research · 2026Article
- Visceral fat, cardiovascular risk factors and quality of life in lupus activity categorised via complement C3.Lupus science & medicine · 2025Article
- Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma.Children (Basel, Switzerland) · 2023Review
- Impact of puberty, sex determinants and chronic inflammation on cardiovascular risk in young people.Frontiers in cardiovascular medicine · 2023Review
- Differential impact of environmental factors on systemic and localized autoimmunity.Frontiers in immunology · 2023Review
- An Exploratory Critical Review on TNF-α as a Potential Inflammatory Biomarker Responsive to Dietary Intervention with Bioactive Foods and Derived Products.Foods (Basel, Switzerland) · 2022Review
- Comorbidity in young patients with juvenile systemic lupus erythematosus: how can we improve management?Clinical rheumatology · 2022Article
- Bariatric surgery in the treatment of adolescent obesity: current perspectives in the United States.Expert review of endocrinology & metabolism · 2021Article
- Obesity is associated with severe clinical course in children with Henoch-Schonlein purpura.Pediatric nephrology (Berlin, Germany) · 2020Article
- Relationship of Excess Weight with Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus Patients.Nutrients · 2019Article
- Review
- Lupus Autoimmunity and Metabolic Parameters Are Exacerbated Upon High Fat Diet-Induced Obesity Due to TLR7 Signaling.Frontiers in immunology · 2019Article
- Pediatric Obesity and the Immune System.Frontiers in pediatrics · 2019Review
- Impact of obesity on autoimmune arthritis and its cardiovascular complications.Autoimmunity reviews · 2018Review
- Opposing Actions of Developmental Trichloroethylene and High-Fat Diet Coexposure on Markers of Lipogenesis and Inflammation in Autoimmune-Prone Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Nutritional intervention in patients with juvenile systemic lupus erythematosus: protective effect against the increase in fat mass.Rheumatology international · 2018Article
- Serum IP-10 is useful for identifying renal and overall disease activity in pediatric systemic lupus erythematosus.Pediatric nephrology (Berlin, Germany) · 2018Article
- Growth Pattern in Children with Systemic Lupus Erythematosus.Oman medical journal · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn systemic lupus erythematosus (SLE), atherosclerosis is attributed to traditional and lupus related risk factors, including metabolic syndrome (MetS), obesity, and inflammation. Objective. To evaluate the association between obesity, measures of body fat content, serum tumor necrosis factor alpha (TNF-α), and interleukin (IL)-6 and -10 levels in childhood-onset SLE (cSLE).
methodsWe screened consecutive cSLE patients followed up in the Pediatric Rheumatology Outpatient Clinic of the State University of Campinas. cSLE patients were assessed for disease and damage. Obesity was definite as body mass index (BMI) ≥30 kg/m(2). Serum TNF-α, IL-6, and IL-10 levels were measured by ELISA. Dual-energy X-ray absorptiometry was used to determine total fat mass, lean mass, and percent of body fat.
resultsWe included 52 cSLE patients and 52 controls. cSLE patients had higher serum TNF-α (P = 0.004), IL-6 (P = 0.002), and IL-10 (P < 0.001) levels compared to controls. We observed higher serum TNF-α (P = 0.036) levels in cSLE patients with obesity. An association between serum TNF-α levels and body fat percent (P = 0.046) and total fat mass on trunk region (P = 0.035) was observed.
conclusionSerum TNF-α levels were associated with obesity and body fat content in cSLE. Our finding suggests that obesity may contribute to the increase of serum TNF-α levels in cSLE.
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