ReviewJournal of clinical neonatology2014
Predicting disease severity of necrotizing enterocolitis: how to identify infants for future novel therapies.
Review in Journal of clinical neonatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of the role of Doppler ultrasonography of the superior mesenteric artery in detecting neonates at risk of necrotizing enterocolitis.Pediatric radiology · 2023Pooled it
- Protective effects of different doses of human milk on neonatal necrotizing enterocolitis.Medicine · 2020Pooled it
- Role of innate T cells in necrotizing enterocolitis.Frontiers in immunology · 2024Review
- Article
- Predictive value of serum markers in the operation evaluation of neonatal necrotizing enterocolitis.Translational pediatrics · 2023Article
- Prediction of High Bell Stages of Necrotizing Enterocolitis Using a Mathematic Formula for Risk Determination.Children (Basel, Switzerland) · 2022Article
- The benefits, limitations and opportunities of preclinical models for neonatal drug development.Disease models & mechanisms · 2022Review
- Predictive factors for surgical treatment in preterm neonates with necrotizing enterocolitis: a multicenter case-control study.European journal of pediatrics · 2021Article
- The role of imaging in the management of necrotising enterocolitis: a multispecialist survey and a review of the literature.European radiology · 2018Review
- Significance of dynamic evolution of TNF-α, IL-6 and intestinal fatty acid-binding protein levels in neonatal necrotizing enterocolitis.Experimental and therapeutic medicine · 2018Article
- Surgical necrotizing enterocolitis.Seminars in perinatology · 2017Review
- Heavy metals exposure levels and their correlation with different clinical forms of fetal growth restriction.PloS one · 2017Article
- Current Knowledge of Necrotizing Enterocolitis in Preterm Infants and the Impact of Different Types of Enteral Nutrition Products.Advances in nutrition (Bethesda, Md.) · 2017Review
- A Causal Network Analysis of the Fatty Acid Metabolome in African-Americans Reveals a Critical Role for Palmitoleate and Margarate.Omics : a journal of integrative biology · 2016Article
- Propofol administration to the maternal-fetal unit improved fetal EEG and influenced cerebral apoptotic pathway in preterm lambs suffering from severe asphyxia.Molecular and cellular pediatrics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotizing enterocolitis (NEC) remains a very devastating problem within the very low birth weight neonatal population. Several experimental therapies are being tested in animal models and soon may be ready for human trials. Despite this progress, we currently have no way to identify infants who would be optimal targets for therapy. Specifically, we are unable to predict which infants will progress to the more severe Bell's stage of disease that may necessitate surgery. Ideally, an algorithm could be constructed that would encompass multiple neonatal and maternal risk factors as well as potential biologic markers of disease so that these infants could be identified in a more timely fashion. This review summarizes the known risk factors and biomarkers of disease in hopes of stimulating clinical research to identify such an "early warning" NEC algorithm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.